Cargando…
Understanding Rad51 function is a prerequisite for progress in cancer research
The human protein Rad51 is double-edged in cancer contexts: on one hand, preventing tumourigenesis by eliminating potentially carcinogenic DNA damage and, on the other, promoting tumours by introducing new mutations. Understanding mechanistic details of Rad51 in homologous recombination (HR) and rep...
Autores principales: | Nordén, Bengt, Takahashi, Masayuki |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392672/ https://www.ncbi.nlm.nih.gov/pubmed/37528958 http://dx.doi.org/10.1017/qrd.2020.13 |
Ejemplares similares
-
Regulation and pharmacological targeting of RAD51 in cancer
por: Grundy, McKenzie K, et al.
Publicado: (2020) -
Ca(2+) improves organization of single-stranded DNA bases in human Rad51 filament, explaining stimulatory effect on gene recombination
por: Fornander, Louise H., et al.
Publicado: (2012) -
Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor
por: Greenhough, Luke A., et al.
Publicado: (2023) -
Design of Potent Inhibitors of Human RAD51 Recombinase Based on BRC Motifs of BRCA2 Protein: Modeling and Experimental Validation of a Chimera Peptide
por: Nomme, Julian, et al.
Publicado: (2010) -
Swi5-Sfr1 protein stimulates Rad51-mediated DNA strand exchange reaction through organization of DNA bases in the presynaptic filament
por: Fornander, Louise H., et al.
Publicado: (2014)