PIP5K1C phosphoinositide kinase deficiency distinguishes PIKFYVE-dependent cancer cells from non-malignant cells

Although PIKFYVE phosphoinositide kinase inhibitors can selectively eliminate PIKFYVE-dependent human cancer cells in vitro and in vivo, the basis for this selectivity has remained elusive. Here we show that the sensitivity of cells to the PIKFYVE inhibitor WX8 is not linked to PIKFYVE expression, m...

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Detalles Bibliográficos
Autores principales: Roy, Ajit, Chakraborty, Arup R., Nomanbhoy, Tyzoon, DePamphilis, Melvin L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392749/
https://www.ncbi.nlm.nih.gov/pubmed/36803256
http://dx.doi.org/10.1080/15548627.2023.2182594

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