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The Underlying Mechanisms of Sleep Deprivation Exacerbating Neuropathic Pain

Pain disrupts sleep, and sleep deprivation or interference can alter pain perception in animals and humans, for example by increasing sensitivity to pain. However, the mechanism by which sleep affects neuropathic pain remains unclear. In this review, we discuss the available evidence from the epidem...

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Detalles Bibliográficos
Autores principales: Zhu, Manmin, Huang, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392808/
https://www.ncbi.nlm.nih.gov/pubmed/37533626
http://dx.doi.org/10.2147/NSS.S414174
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author Zhu, Manmin
Huang, Hao
author_facet Zhu, Manmin
Huang, Hao
author_sort Zhu, Manmin
collection PubMed
description Pain disrupts sleep, and sleep deprivation or interference can alter pain perception in animals and humans, for example by increasing sensitivity to pain. However, the mechanism by which sleep affects neuropathic pain remains unclear. In this review, we discuss the available evidence from the epidemiologic, clinical, and human, as well as laboratory studies. In previous studies, we have found that sleep deprivation affects various injurious systems, including opioids, dopaminergic, immune, orexins, hypothalamic-pituitary-adrenal axis, and adenosine. At the same time, these systems play a crucial role in neuropathic pain regulation. In the complex interactions between these neurobiological systems, there may be potential regulatory pathways through which sleep deprivation amplifies neuropathic pain. Because of the impact sleep problems and neuropathic pain can have on the patients’ quality of life, studying the link between sleep and neuropathic pain is important for neuropathic pain prevention and public health.
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spelling pubmed-103928082023-08-02 The Underlying Mechanisms of Sleep Deprivation Exacerbating Neuropathic Pain Zhu, Manmin Huang, Hao Nat Sci Sleep Review Pain disrupts sleep, and sleep deprivation or interference can alter pain perception in animals and humans, for example by increasing sensitivity to pain. However, the mechanism by which sleep affects neuropathic pain remains unclear. In this review, we discuss the available evidence from the epidemiologic, clinical, and human, as well as laboratory studies. In previous studies, we have found that sleep deprivation affects various injurious systems, including opioids, dopaminergic, immune, orexins, hypothalamic-pituitary-adrenal axis, and adenosine. At the same time, these systems play a crucial role in neuropathic pain regulation. In the complex interactions between these neurobiological systems, there may be potential regulatory pathways through which sleep deprivation amplifies neuropathic pain. Because of the impact sleep problems and neuropathic pain can have on the patients’ quality of life, studying the link between sleep and neuropathic pain is important for neuropathic pain prevention and public health. Dove 2023-07-28 /pmc/articles/PMC10392808/ /pubmed/37533626 http://dx.doi.org/10.2147/NSS.S414174 Text en © 2023 Zhu and Huang. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Zhu, Manmin
Huang, Hao
The Underlying Mechanisms of Sleep Deprivation Exacerbating Neuropathic Pain
title The Underlying Mechanisms of Sleep Deprivation Exacerbating Neuropathic Pain
title_full The Underlying Mechanisms of Sleep Deprivation Exacerbating Neuropathic Pain
title_fullStr The Underlying Mechanisms of Sleep Deprivation Exacerbating Neuropathic Pain
title_full_unstemmed The Underlying Mechanisms of Sleep Deprivation Exacerbating Neuropathic Pain
title_short The Underlying Mechanisms of Sleep Deprivation Exacerbating Neuropathic Pain
title_sort underlying mechanisms of sleep deprivation exacerbating neuropathic pain
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392808/
https://www.ncbi.nlm.nih.gov/pubmed/37533626
http://dx.doi.org/10.2147/NSS.S414174
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