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Comparison of the Effect of Heparinized Normal Saline Solution Versus Saline Solutions in Arterial and Central Venous Catheters on Complete Blood Count After Cardiac Surgery

BACKGROUND: Heparinized and saline solutions can prevent clot formation in arterial and central venous catheters. However, heparin can decrease the platelet count and induce thrombocytopenia. Patients undergoing cardiac surgeries are more likely to develop heparin-induced thrombocytopenia. OBJECTIVE...

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Autores principales: Ziyaeifard, Mohsen, Ferasat-Kish, Rasool, Azarfarin, Rasoul, Aghdaii, Nahid, Nejatisini, Hasan, Azadi Ahmadabadi, Changiz, Yousefi, Marziyeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Brieflands 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392822/
https://www.ncbi.nlm.nih.gov/pubmed/37533479
http://dx.doi.org/10.5812/aapm-113345
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author Ziyaeifard, Mohsen
Ferasat-Kish, Rasool
Azarfarin, Rasoul
Aghdaii, Nahid
Nejatisini, Hasan
Azadi Ahmadabadi, Changiz
Yousefi, Marziyeh
author_facet Ziyaeifard, Mohsen
Ferasat-Kish, Rasool
Azarfarin, Rasoul
Aghdaii, Nahid
Nejatisini, Hasan
Azadi Ahmadabadi, Changiz
Yousefi, Marziyeh
author_sort Ziyaeifard, Mohsen
collection PubMed
description BACKGROUND: Heparinized and saline solutions can prevent clot formation in arterial and central venous catheters. However, heparin can decrease the platelet count and induce thrombocytopenia. Patients undergoing cardiac surgeries are more likely to develop heparin-induced thrombocytopenia. OBJECTIVES: This study aimed to investigate the effect of heparinized and saline solutions of arterial and central venous catheters on complete blood count (CBC) after cardiac surgery. METHODS: This randomized controlled trial was conducted on 100 participants. All subjects underwent cardiac surgery at Rajaie Cardiovascular, Medical, and Research Center, Tehran, Iran. Patients were randomly divided into two groups intervention (A) for whom heparinized normal saline solution was used to maintain central arterial and venous catheters, and control (B) for whom normal saline solution was used. The CBC of subjects was monitored for three days (before surgery and the first and second days after surgery). RESULTS: In the present study, there were no significant differences between CBC, white blood cell differential count, prothrombin time, partial thromboplastin time (PTT), and international normalized ratio in groups A and B. However, we found significant differences in platelet count (P = 0.049), red blood cell count (P = 0.0001), hemoglobin (P = 0.0001), and hematocrit (P = 0.0001) between before surgery and the second day after surgery in group A. Platelet count (P = 0.027) and PTT (P = 0.0001) before and after surgery were significantly different in group B. CONCLUSIONS: According to the results of this study, normal saline solution catheters have fewer side effects and can be a suitable replacement for heparinized catheters.
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spelling pubmed-103928222023-08-02 Comparison of the Effect of Heparinized Normal Saline Solution Versus Saline Solutions in Arterial and Central Venous Catheters on Complete Blood Count After Cardiac Surgery Ziyaeifard, Mohsen Ferasat-Kish, Rasool Azarfarin, Rasoul Aghdaii, Nahid Nejatisini, Hasan Azadi Ahmadabadi, Changiz Yousefi, Marziyeh Anesth Pain Med Brief Report BACKGROUND: Heparinized and saline solutions can prevent clot formation in arterial and central venous catheters. However, heparin can decrease the platelet count and induce thrombocytopenia. Patients undergoing cardiac surgeries are more likely to develop heparin-induced thrombocytopenia. OBJECTIVES: This study aimed to investigate the effect of heparinized and saline solutions of arterial and central venous catheters on complete blood count (CBC) after cardiac surgery. METHODS: This randomized controlled trial was conducted on 100 participants. All subjects underwent cardiac surgery at Rajaie Cardiovascular, Medical, and Research Center, Tehran, Iran. Patients were randomly divided into two groups intervention (A) for whom heparinized normal saline solution was used to maintain central arterial and venous catheters, and control (B) for whom normal saline solution was used. The CBC of subjects was monitored for three days (before surgery and the first and second days after surgery). RESULTS: In the present study, there were no significant differences between CBC, white blood cell differential count, prothrombin time, partial thromboplastin time (PTT), and international normalized ratio in groups A and B. However, we found significant differences in platelet count (P = 0.049), red blood cell count (P = 0.0001), hemoglobin (P = 0.0001), and hematocrit (P = 0.0001) between before surgery and the second day after surgery in group A. Platelet count (P = 0.027) and PTT (P = 0.0001) before and after surgery were significantly different in group B. CONCLUSIONS: According to the results of this study, normal saline solution catheters have fewer side effects and can be a suitable replacement for heparinized catheters. Brieflands 2022-08-23 /pmc/articles/PMC10392822/ /pubmed/37533479 http://dx.doi.org/10.5812/aapm-113345 Text en Copyright © 2022, Author(s) https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
spellingShingle Brief Report
Ziyaeifard, Mohsen
Ferasat-Kish, Rasool
Azarfarin, Rasoul
Aghdaii, Nahid
Nejatisini, Hasan
Azadi Ahmadabadi, Changiz
Yousefi, Marziyeh
Comparison of the Effect of Heparinized Normal Saline Solution Versus Saline Solutions in Arterial and Central Venous Catheters on Complete Blood Count After Cardiac Surgery
title Comparison of the Effect of Heparinized Normal Saline Solution Versus Saline Solutions in Arterial and Central Venous Catheters on Complete Blood Count After Cardiac Surgery
title_full Comparison of the Effect of Heparinized Normal Saline Solution Versus Saline Solutions in Arterial and Central Venous Catheters on Complete Blood Count After Cardiac Surgery
title_fullStr Comparison of the Effect of Heparinized Normal Saline Solution Versus Saline Solutions in Arterial and Central Venous Catheters on Complete Blood Count After Cardiac Surgery
title_full_unstemmed Comparison of the Effect of Heparinized Normal Saline Solution Versus Saline Solutions in Arterial and Central Venous Catheters on Complete Blood Count After Cardiac Surgery
title_short Comparison of the Effect of Heparinized Normal Saline Solution Versus Saline Solutions in Arterial and Central Venous Catheters on Complete Blood Count After Cardiac Surgery
title_sort comparison of the effect of heparinized normal saline solution versus saline solutions in arterial and central venous catheters on complete blood count after cardiac surgery
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392822/
https://www.ncbi.nlm.nih.gov/pubmed/37533479
http://dx.doi.org/10.5812/aapm-113345
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