TNF+ regulatory T cells regulate the stemness of gastric cancer cells through the IL13/STAT3 pathway

Regulatory T cells (Tregs) are an important component of the tumor microenvironment; however, the interaction between Tregs and gastric cancer cells is not completely understood. Recent studies have shown that Tregs participate in cancer cell stemness maintenance. In this study, we performed single-...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Rou, Cao, Guanjie, Zhang, Baogui, Wei, Li, Zhang, Xiaobei, Jin, Meng, He, Baoyu, Zhang, Bin, He, Zhun, Bie, Qingli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392945/
https://www.ncbi.nlm.nih.gov/pubmed/37534250
http://dx.doi.org/10.3389/fonc.2023.1162938
_version_ 1785083058379030528
author Zhao, Rou
Cao, Guanjie
Zhang, Baogui
Wei, Li
Zhang, Xiaobei
Jin, Meng
He, Baoyu
Zhang, Bin
He, Zhun
Bie, Qingli
author_facet Zhao, Rou
Cao, Guanjie
Zhang, Baogui
Wei, Li
Zhang, Xiaobei
Jin, Meng
He, Baoyu
Zhang, Bin
He, Zhun
Bie, Qingli
author_sort Zhao, Rou
collection PubMed
description Regulatory T cells (Tregs) are an important component of the tumor microenvironment; however, the interaction between Tregs and gastric cancer cells is not completely understood. Recent studies have shown that Tregs participate in cancer cell stemness maintenance. In this study, we performed single-cell RNA sequencing of gastric cancer and adjacent tissues and found that Tregs with high TNF expression were recruited to gastric cancer tissues and were significantly correlated with patient survival. TNF+ Tregs significantly contribute to tumor growth and progression. Our studies have further demonstrated that TNF+ Tregs promote the stemness of gastric cancer cells through the IL13/STAT3 pathway. Therefore, blocking the interaction between TNF+ Tregs and gastric cancer cells may be a new approach in the treatment of gastric cancer.
format Online
Article
Text
id pubmed-10392945
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-103929452023-08-02 TNF+ regulatory T cells regulate the stemness of gastric cancer cells through the IL13/STAT3 pathway Zhao, Rou Cao, Guanjie Zhang, Baogui Wei, Li Zhang, Xiaobei Jin, Meng He, Baoyu Zhang, Bin He, Zhun Bie, Qingli Front Oncol Oncology Regulatory T cells (Tregs) are an important component of the tumor microenvironment; however, the interaction between Tregs and gastric cancer cells is not completely understood. Recent studies have shown that Tregs participate in cancer cell stemness maintenance. In this study, we performed single-cell RNA sequencing of gastric cancer and adjacent tissues and found that Tregs with high TNF expression were recruited to gastric cancer tissues and were significantly correlated with patient survival. TNF+ Tregs significantly contribute to tumor growth and progression. Our studies have further demonstrated that TNF+ Tregs promote the stemness of gastric cancer cells through the IL13/STAT3 pathway. Therefore, blocking the interaction between TNF+ Tregs and gastric cancer cells may be a new approach in the treatment of gastric cancer. Frontiers Media S.A. 2023-07-18 /pmc/articles/PMC10392945/ /pubmed/37534250 http://dx.doi.org/10.3389/fonc.2023.1162938 Text en Copyright © 2023 Zhao, Cao, Zhang, Wei, Zhang, Jin, He, Zhang, He and Bie https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Zhao, Rou
Cao, Guanjie
Zhang, Baogui
Wei, Li
Zhang, Xiaobei
Jin, Meng
He, Baoyu
Zhang, Bin
He, Zhun
Bie, Qingli
TNF+ regulatory T cells regulate the stemness of gastric cancer cells through the IL13/STAT3 pathway
title TNF+ regulatory T cells regulate the stemness of gastric cancer cells through the IL13/STAT3 pathway
title_full TNF+ regulatory T cells regulate the stemness of gastric cancer cells through the IL13/STAT3 pathway
title_fullStr TNF+ regulatory T cells regulate the stemness of gastric cancer cells through the IL13/STAT3 pathway
title_full_unstemmed TNF+ regulatory T cells regulate the stemness of gastric cancer cells through the IL13/STAT3 pathway
title_short TNF+ regulatory T cells regulate the stemness of gastric cancer cells through the IL13/STAT3 pathway
title_sort tnf+ regulatory t cells regulate the stemness of gastric cancer cells through the il13/stat3 pathway
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10392945/
https://www.ncbi.nlm.nih.gov/pubmed/37534250
http://dx.doi.org/10.3389/fonc.2023.1162938
work_keys_str_mv AT zhaorou tnfregulatorytcellsregulatethestemnessofgastriccancercellsthroughtheil13stat3pathway
AT caoguanjie tnfregulatorytcellsregulatethestemnessofgastriccancercellsthroughtheil13stat3pathway
AT zhangbaogui tnfregulatorytcellsregulatethestemnessofgastriccancercellsthroughtheil13stat3pathway
AT weili tnfregulatorytcellsregulatethestemnessofgastriccancercellsthroughtheil13stat3pathway
AT zhangxiaobei tnfregulatorytcellsregulatethestemnessofgastriccancercellsthroughtheil13stat3pathway
AT jinmeng tnfregulatorytcellsregulatethestemnessofgastriccancercellsthroughtheil13stat3pathway
AT hebaoyu tnfregulatorytcellsregulatethestemnessofgastriccancercellsthroughtheil13stat3pathway
AT zhangbin tnfregulatorytcellsregulatethestemnessofgastriccancercellsthroughtheil13stat3pathway
AT hezhun tnfregulatorytcellsregulatethestemnessofgastriccancercellsthroughtheil13stat3pathway
AT bieqingli tnfregulatorytcellsregulatethestemnessofgastriccancercellsthroughtheil13stat3pathway

Ejemplares similares