Smooth muscle α-actin missense variant promotes atherosclerosis through modulation of intracellular cholesterol in smooth muscle cells

AIMS: The variant p.Arg149Cys in ACTA2, which encodes smooth muscle cell (SMC)-specific α-actin, predisposes to thoracic aortic disease and early onset coronary artery disease in individuals without cardiovascular risk factors. This study investigated how this variant drives increased atherosclerosi...

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Detalles Bibliográficos
Autores principales: Kaw, Kaveeta, Chattopadhyay, Abhijnan, Guan, Pujun, Chen, Jiyuan, Majumder, Suravi, Duan, Xue-yan, Ma, Shuangtao, Zhang, Chen, Kwartler, Callie S, Milewicz, Dianna M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Translational Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393072/
https://www.ncbi.nlm.nih.gov/pubmed/37377039
http://dx.doi.org/10.1093/eurheartj/ehad373

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393072/
https://www.ncbi.nlm.nih.gov/pubmed/37377039
http://dx.doi.org/10.1093/eurheartj/ehad373

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