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Correlation between Subclinical Hypothyroidism and Metabolic Syndrome: A Retrospective Study
BACKGROUND: Several studies worldwide have studied the correlation between subclinical hypothyroidism (SCH), and metabolic syndrome (MetS), but have reported inconsistent findings. OBJECTIVES: To assess the correlation between SCH and MetS in a population from Saudi Arabia. METHODS: This retrospecti...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393097/ https://www.ncbi.nlm.nih.gov/pubmed/37533656 http://dx.doi.org/10.4103/sjmms.sjmms_225_22 |
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author | Alsulami, Salhah Saleh Baig, Mukhtiar Albeladi, Atheer Hameed Alyoubi, Shahad Bandar Alsubaie, Shahad Alhumaidi Albeladi, Samah Abdulsalam Ghamri, Kholoud Alawi Alraiqi, Abeer Mohammed Saeed Alyoubi, Safa Mobarak Almutairi, Wesam Aied |
author_facet | Alsulami, Salhah Saleh Baig, Mukhtiar Albeladi, Atheer Hameed Alyoubi, Shahad Bandar Alsubaie, Shahad Alhumaidi Albeladi, Samah Abdulsalam Ghamri, Kholoud Alawi Alraiqi, Abeer Mohammed Saeed Alyoubi, Safa Mobarak Almutairi, Wesam Aied |
author_sort | Alsulami, Salhah Saleh |
collection | PubMed |
description | BACKGROUND: Several studies worldwide have studied the correlation between subclinical hypothyroidism (SCH), and metabolic syndrome (MetS), but have reported inconsistent findings. OBJECTIVES: To assess the correlation between SCH and MetS in a population from Saudi Arabia. METHODS: This retrospective study was conducted at King Abdulaziz University Hospital and analyzed all thyroid function tests conducted between January 1, 2019, to December 31, 2021. A predesigned checklist was used to collect data about patients’ characteristics such as age, gender, nationality, TSH, FT4 level, and MetS components. RESULTS: A total of 41,519 thyroid function tests were conducted during the study period. From this, 1303 (3.1%) patients were found to have SCH, with the majority being females (74.4%). The prevalence did not differ according to gender but increased to 3.5% among those aged >60 years. MetS components between mildly and markedly elevated TSH were significant for total cholesterol (P < 0.001) and high-density lipoprotein cholesterol (P < 0.05). Male patients with SCH were at a higher risk of developing diabetes (P < 0.001) and hypertension (P < 0.02), than female patients with SCH. After adjusting for age, in the multiple stepwise linear regression analysis, a significant association was found between TSH levels and ALT (odds ratio: 0.77) and SBP (odds ratio: 0.35). CONCLUSION: The study demonstrated that the prevalence of SCH is similar between both genders but increases with age. MetS components were abnormal in patients aged >50 years and in males with SCH. SCH and MetS components were found to be correlated, and thus monitoring these variables in patients with SCH is advisable. |
format | Online Article Text |
id | pubmed-10393097 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-103930972023-08-02 Correlation between Subclinical Hypothyroidism and Metabolic Syndrome: A Retrospective Study Alsulami, Salhah Saleh Baig, Mukhtiar Albeladi, Atheer Hameed Alyoubi, Shahad Bandar Alsubaie, Shahad Alhumaidi Albeladi, Samah Abdulsalam Ghamri, Kholoud Alawi Alraiqi, Abeer Mohammed Saeed Alyoubi, Safa Mobarak Almutairi, Wesam Aied Saudi J Med Med Sci Original Article BACKGROUND: Several studies worldwide have studied the correlation between subclinical hypothyroidism (SCH), and metabolic syndrome (MetS), but have reported inconsistent findings. OBJECTIVES: To assess the correlation between SCH and MetS in a population from Saudi Arabia. METHODS: This retrospective study was conducted at King Abdulaziz University Hospital and analyzed all thyroid function tests conducted between January 1, 2019, to December 31, 2021. A predesigned checklist was used to collect data about patients’ characteristics such as age, gender, nationality, TSH, FT4 level, and MetS components. RESULTS: A total of 41,519 thyroid function tests were conducted during the study period. From this, 1303 (3.1%) patients were found to have SCH, with the majority being females (74.4%). The prevalence did not differ according to gender but increased to 3.5% among those aged >60 years. MetS components between mildly and markedly elevated TSH were significant for total cholesterol (P < 0.001) and high-density lipoprotein cholesterol (P < 0.05). Male patients with SCH were at a higher risk of developing diabetes (P < 0.001) and hypertension (P < 0.02), than female patients with SCH. After adjusting for age, in the multiple stepwise linear regression analysis, a significant association was found between TSH levels and ALT (odds ratio: 0.77) and SBP (odds ratio: 0.35). CONCLUSION: The study demonstrated that the prevalence of SCH is similar between both genders but increases with age. MetS components were abnormal in patients aged >50 years and in males with SCH. SCH and MetS components were found to be correlated, and thus monitoring these variables in patients with SCH is advisable. Wolters Kluwer - Medknow 2023 2023-07-15 /pmc/articles/PMC10393097/ /pubmed/37533656 http://dx.doi.org/10.4103/sjmms.sjmms_225_22 Text en Copyright: © 2023 Saudi Journal of Medicine & Medical Sciences https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Alsulami, Salhah Saleh Baig, Mukhtiar Albeladi, Atheer Hameed Alyoubi, Shahad Bandar Alsubaie, Shahad Alhumaidi Albeladi, Samah Abdulsalam Ghamri, Kholoud Alawi Alraiqi, Abeer Mohammed Saeed Alyoubi, Safa Mobarak Almutairi, Wesam Aied Correlation between Subclinical Hypothyroidism and Metabolic Syndrome: A Retrospective Study |
title | Correlation between Subclinical Hypothyroidism and Metabolic Syndrome: A Retrospective Study |
title_full | Correlation between Subclinical Hypothyroidism and Metabolic Syndrome: A Retrospective Study |
title_fullStr | Correlation between Subclinical Hypothyroidism and Metabolic Syndrome: A Retrospective Study |
title_full_unstemmed | Correlation between Subclinical Hypothyroidism and Metabolic Syndrome: A Retrospective Study |
title_short | Correlation between Subclinical Hypothyroidism and Metabolic Syndrome: A Retrospective Study |
title_sort | correlation between subclinical hypothyroidism and metabolic syndrome: a retrospective study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393097/ https://www.ncbi.nlm.nih.gov/pubmed/37533656 http://dx.doi.org/10.4103/sjmms.sjmms_225_22 |
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