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Municipality-level measles, mumps, and rubella (MMR) vaccine coverage and deprivation in Brazil: A nationwide ecological study, 2006 to 2020

To better understand the declining rates of routine childhood vaccination in Brazil, we investigated the association between measles, mumps, and rubella (MMR) first dose vaccine coverage and deprivation at the municipality level. Using routinely collected data from 5565 Brazilian municipalities from...

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Autores principales: Godin, Audrey, Pescarini, Julia M., Raja, Amber I., Paixao, Enny S., Ichihara, Maria Yury, Sato, Ana Paula S., Smeeth, Liam, Barreto, Mauricio L., Brickley, Elizabeth B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393142/
https://www.ncbi.nlm.nih.gov/pubmed/37527234
http://dx.doi.org/10.1371/journal.pgph.0002027
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author Godin, Audrey
Pescarini, Julia M.
Raja, Amber I.
Paixao, Enny S.
Ichihara, Maria Yury
Sato, Ana Paula S.
Smeeth, Liam
Barreto, Mauricio L.
Brickley, Elizabeth B.
author_facet Godin, Audrey
Pescarini, Julia M.
Raja, Amber I.
Paixao, Enny S.
Ichihara, Maria Yury
Sato, Ana Paula S.
Smeeth, Liam
Barreto, Mauricio L.
Brickley, Elizabeth B.
author_sort Godin, Audrey
collection PubMed
description To better understand the declining rates of routine childhood vaccination in Brazil, we investigated the association between measles, mumps, and rubella (MMR) first dose vaccine coverage and deprivation at the municipality level. Using routinely collected data from 5565 Brazilian municipalities from 2006 to 2020, we investigated the association between municipality-level MMR vaccine first dose coverage (i.e., as a continuous variable and as a percentage of municipalities attaining the 95% target coverage) in relation to quintiles of municipality-level deprivation, measured by the Brazilian Deprivation Index (Índice Brasileiro de Privação, IBP), and geographic regions. From 2006 to 2020, the mean municipality-level MMR vaccine coverage declined across all deprivation quintiles and regions of Brazil, by an average of 1.2% per year. The most deprived quintile of municipalities had higher coverage on average, but also the steepest declines in coverage (i.e., an annual decline of 1.64% versus 0.61% in the least deprived quintile) in the period of 2006–2020, and the largest drop in coverage at the beginning of the COVID-19 pandemic (2019–2020). Across all deprivation quintiles and regions (except for the Southeast region), less than 50% of municipalities in Brazil met the 95% MMR coverage target in 2020.The decrease in MMR first dose vaccine coverage in Brazil is widespread, but steeper declines have been observed in the most deprived municipalities. To promote vaccine equity and prevent future outbreaks, further research is urgently needed to understand the causal mechanisms underlying the observed associations between municipality-level MMR vaccine coverage and deprivation.
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spelling pubmed-103931422023-08-02 Municipality-level measles, mumps, and rubella (MMR) vaccine coverage and deprivation in Brazil: A nationwide ecological study, 2006 to 2020 Godin, Audrey Pescarini, Julia M. Raja, Amber I. Paixao, Enny S. Ichihara, Maria Yury Sato, Ana Paula S. Smeeth, Liam Barreto, Mauricio L. Brickley, Elizabeth B. PLOS Glob Public Health Research Article To better understand the declining rates of routine childhood vaccination in Brazil, we investigated the association between measles, mumps, and rubella (MMR) first dose vaccine coverage and deprivation at the municipality level. Using routinely collected data from 5565 Brazilian municipalities from 2006 to 2020, we investigated the association between municipality-level MMR vaccine first dose coverage (i.e., as a continuous variable and as a percentage of municipalities attaining the 95% target coverage) in relation to quintiles of municipality-level deprivation, measured by the Brazilian Deprivation Index (Índice Brasileiro de Privação, IBP), and geographic regions. From 2006 to 2020, the mean municipality-level MMR vaccine coverage declined across all deprivation quintiles and regions of Brazil, by an average of 1.2% per year. The most deprived quintile of municipalities had higher coverage on average, but also the steepest declines in coverage (i.e., an annual decline of 1.64% versus 0.61% in the least deprived quintile) in the period of 2006–2020, and the largest drop in coverage at the beginning of the COVID-19 pandemic (2019–2020). Across all deprivation quintiles and regions (except for the Southeast region), less than 50% of municipalities in Brazil met the 95% MMR coverage target in 2020.The decrease in MMR first dose vaccine coverage in Brazil is widespread, but steeper declines have been observed in the most deprived municipalities. To promote vaccine equity and prevent future outbreaks, further research is urgently needed to understand the causal mechanisms underlying the observed associations between municipality-level MMR vaccine coverage and deprivation. Public Library of Science 2023-08-01 /pmc/articles/PMC10393142/ /pubmed/37527234 http://dx.doi.org/10.1371/journal.pgph.0002027 Text en © 2023 Godin et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Godin, Audrey
Pescarini, Julia M.
Raja, Amber I.
Paixao, Enny S.
Ichihara, Maria Yury
Sato, Ana Paula S.
Smeeth, Liam
Barreto, Mauricio L.
Brickley, Elizabeth B.
Municipality-level measles, mumps, and rubella (MMR) vaccine coverage and deprivation in Brazil: A nationwide ecological study, 2006 to 2020
title Municipality-level measles, mumps, and rubella (MMR) vaccine coverage and deprivation in Brazil: A nationwide ecological study, 2006 to 2020
title_full Municipality-level measles, mumps, and rubella (MMR) vaccine coverage and deprivation in Brazil: A nationwide ecological study, 2006 to 2020
title_fullStr Municipality-level measles, mumps, and rubella (MMR) vaccine coverage and deprivation in Brazil: A nationwide ecological study, 2006 to 2020
title_full_unstemmed Municipality-level measles, mumps, and rubella (MMR) vaccine coverage and deprivation in Brazil: A nationwide ecological study, 2006 to 2020
title_short Municipality-level measles, mumps, and rubella (MMR) vaccine coverage and deprivation in Brazil: A nationwide ecological study, 2006 to 2020
title_sort municipality-level measles, mumps, and rubella (mmr) vaccine coverage and deprivation in brazil: a nationwide ecological study, 2006 to 2020
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393142/
https://www.ncbi.nlm.nih.gov/pubmed/37527234
http://dx.doi.org/10.1371/journal.pgph.0002027
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