The DNMT3A ADD domain is required for efficient de novo DNA methylation and maternal imprinting in mouse oocytes

Establishment of a proper DNA methylation landscape in mammalian oocytes is important for maternal imprinting and embryonic development. De novo DNA methylation in oocytes is mediated by the DNA methyltransferase DNMT3A, which has an ATRX-DNMT3-DNMT3L (ADD) domain that interacts with histone H3 tail...

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Detalles Bibliográficos
Autores principales: Uehara, Ryuji, Au Yeung, Wan Kin, Toriyama, Keisuke, Ohishi, Hiroaki, Kubo, Naoki, Toh, Hidehiro, Suetake, Isao, Shirane, Kenjiro, Sasaki, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393158/
https://www.ncbi.nlm.nih.gov/pubmed/37527244
http://dx.doi.org/10.1371/journal.pgen.1010855

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393158/
https://www.ncbi.nlm.nih.gov/pubmed/37527244
http://dx.doi.org/10.1371/journal.pgen.1010855

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