Translational regulation by uORFs and start codon selection stringency

In addition to the main, protein-coding, open reading frame (mORF), many eukaryotic mRNAs contain upstream ORFs (uORFs) initiated at AUG or near-cognate codons residing 5′ of the mORF start site. Whereas translation of uORFs generally represses translation of the mORFs, a subset of uORFs serves as a...

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Detalles Bibliográficos
Autores principales: Dever, Thomas E., Ivanov, Ivaylo P., Hinnebusch, Alan G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2023
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393191/
https://www.ncbi.nlm.nih.gov/pubmed/37433636
http://dx.doi.org/10.1101/gad.350752.123
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author Dever, Thomas E.
Ivanov, Ivaylo P.
Hinnebusch, Alan G.
author_facet Dever, Thomas E.
Ivanov, Ivaylo P.
Hinnebusch, Alan G.
author_sort Dever, Thomas E.
collection PubMed
description In addition to the main, protein-coding, open reading frame (mORF), many eukaryotic mRNAs contain upstream ORFs (uORFs) initiated at AUG or near-cognate codons residing 5′ of the mORF start site. Whereas translation of uORFs generally represses translation of the mORFs, a subset of uORFs serves as a nexus for regulating translation of the mORF. In this review, we summarize the mechanisms by which uORFs can repress or stimulate mRNA translation, highlight uORF-mediated translational repression involving ribosome queuing, and critically evaluate recently described alternatives to the delayed reinitiation model for uORF-mediated regulation of the GCN4/ATF4 mRNAs.
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spelling pubmed-103931912023-08-02 Translational regulation by uORFs and start codon selection stringency Dever, Thomas E. Ivanov, Ivaylo P. Hinnebusch, Alan G. Genes Dev Reviews In addition to the main, protein-coding, open reading frame (mORF), many eukaryotic mRNAs contain upstream ORFs (uORFs) initiated at AUG or near-cognate codons residing 5′ of the mORF start site. Whereas translation of uORFs generally represses translation of the mORFs, a subset of uORFs serves as a nexus for regulating translation of the mORF. In this review, we summarize the mechanisms by which uORFs can repress or stimulate mRNA translation, highlight uORF-mediated translational repression involving ribosome queuing, and critically evaluate recently described alternatives to the delayed reinitiation model for uORF-mediated regulation of the GCN4/ATF4 mRNAs. Cold Spring Harbor Laboratory Press 2023-06-01 /pmc/articles/PMC10393191/ /pubmed/37433636 http://dx.doi.org/10.1101/gad.350752.123 Text en Published by Cold Spring Harbor Laboratory Press This is a work of the US Government.
spellingShingle Reviews
Dever, Thomas E.
Ivanov, Ivaylo P.
Hinnebusch, Alan G.
Translational regulation by uORFs and start codon selection stringency
title Translational regulation by uORFs and start codon selection stringency
title_full Translational regulation by uORFs and start codon selection stringency
title_fullStr Translational regulation by uORFs and start codon selection stringency
title_full_unstemmed Translational regulation by uORFs and start codon selection stringency
title_short Translational regulation by uORFs and start codon selection stringency
title_sort translational regulation by uorfs and start codon selection stringency
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393191/
https://www.ncbi.nlm.nih.gov/pubmed/37433636
http://dx.doi.org/10.1101/gad.350752.123
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