Differential use of the Nkx2.2 NK2 domain in developing pancreatic islets and neurons

The homeodomain transcription factor (TF) Nkx2.2 governs crucial cell fate decisions in several developing organs, including the central nervous system (CNS), pancreas, and intestine. How Nkx2.2 regulates unique targets in these different systems to impact their individual transcriptional programs r...

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Detalles Bibliográficos
Autores principales: Seymour, Philip A., Serup, Palle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2023
Materias:
Outlook
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393196/
https://www.ncbi.nlm.nih.gov/pubmed/37399332
http://dx.doi.org/10.1101/gad.350895.123
Descripción
Sumario:The homeodomain transcription factor (TF) Nkx2.2 governs crucial cell fate decisions in several developing organs, including the central nervous system (CNS), pancreas, and intestine. How Nkx2.2 regulates unique targets in these different systems to impact their individual transcriptional programs remains unclear. In this issue of Genes & Development Abarinov and colleagues (pp. 490–504) generated and analyzed mice in which the Nkx2.2 SD is mutated and found that the SD is required for normal pancreatic islet differentiation but dispensable for most aspects of neuronal differentiation.

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