Differential use of the Nkx2.2 NK2 domain in developing pancreatic islets and neurons

The homeodomain transcription factor (TF) Nkx2.2 governs crucial cell fate decisions in several developing organs, including the central nervous system (CNS), pancreas, and intestine. How Nkx2.2 regulates unique targets in these different systems to impact their individual transcriptional programs r...

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Detalles Bibliográficos
Autores principales: Seymour, Philip A., Serup, Palle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2023
Materias:
Outlook
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393196/
https://www.ncbi.nlm.nih.gov/pubmed/37399332
http://dx.doi.org/10.1101/gad.350895.123
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author Seymour, Philip A.
Serup, Palle
author_facet Seymour, Philip A.
Serup, Palle
author_sort Seymour, Philip A.
collection PubMed
description The homeodomain transcription factor (TF) Nkx2.2 governs crucial cell fate decisions in several developing organs, including the central nervous system (CNS), pancreas, and intestine. How Nkx2.2 regulates unique targets in these different systems to impact their individual transcriptional programs remains unclear. In this issue of Genes & Development Abarinov and colleagues (pp. 490–504) generated and analyzed mice in which the Nkx2.2 SD is mutated and found that the SD is required for normal pancreatic islet differentiation but dispensable for most aspects of neuronal differentiation.
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spelling pubmed-103931962023-12-01 Differential use of the Nkx2.2 NK2 domain in developing pancreatic islets and neurons Seymour, Philip A. Serup, Palle Genes Dev Outlook The homeodomain transcription factor (TF) Nkx2.2 governs crucial cell fate decisions in several developing organs, including the central nervous system (CNS), pancreas, and intestine. How Nkx2.2 regulates unique targets in these different systems to impact their individual transcriptional programs remains unclear. In this issue of Genes & Development Abarinov and colleagues (pp. 490–504) generated and analyzed mice in which the Nkx2.2 SD is mutated and found that the SD is required for normal pancreatic islet differentiation but dispensable for most aspects of neuronal differentiation. Cold Spring Harbor Laboratory Press 2023-06-01 /pmc/articles/PMC10393196/ /pubmed/37399332 http://dx.doi.org/10.1101/gad.350895.123 Text en © 2023 Seymour and Serup; Published by Cold Spring Harbor Laboratory Press https://creativecommons.org/licenses/by-nc/4.0/This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Outlook
Seymour, Philip A.
Serup, Palle
Differential use of the Nkx2.2 NK2 domain in developing pancreatic islets and neurons
title Differential use of the Nkx2.2 NK2 domain in developing pancreatic islets and neurons
title_full Differential use of the Nkx2.2 NK2 domain in developing pancreatic islets and neurons
title_fullStr Differential use of the Nkx2.2 NK2 domain in developing pancreatic islets and neurons
title_full_unstemmed Differential use of the Nkx2.2 NK2 domain in developing pancreatic islets and neurons
title_short Differential use of the Nkx2.2 NK2 domain in developing pancreatic islets and neurons
title_sort differential use of the nkx2.2 nk2 domain in developing pancreatic islets and neurons
topic Outlook
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393196/
https://www.ncbi.nlm.nih.gov/pubmed/37399332
http://dx.doi.org/10.1101/gad.350895.123
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