Cargando…
The Impact of Disease Activity on Sexual and Erectile Dysfunction in Patients With Inflammatory Bowel Disease
BACKGROUND: Increased disease activity may be a risk factor for sexual dysfunction (SD) in patients with inflammatory bowel disease (IBD). This study investigated associations between objective measures of disease activity and sexual function. METHODS: Adults with IBD undergoing ileocolonoscopy were...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393211/ https://www.ncbi.nlm.nih.gov/pubmed/36166573 http://dx.doi.org/10.1093/ibd/izac204 |
_version_ | 1785083117528154112 |
---|---|
author | Mules, Thomas C Swaminathan, Akhilesh Hirschfeld, Esther Borichevsky, Grace M Frampton, Chris M Day, Andrew S Gearry, Richard B |
author_facet | Mules, Thomas C Swaminathan, Akhilesh Hirschfeld, Esther Borichevsky, Grace M Frampton, Chris M Day, Andrew S Gearry, Richard B |
author_sort | Mules, Thomas C |
collection | PubMed |
description | BACKGROUND: Increased disease activity may be a risk factor for sexual dysfunction (SD) in patients with inflammatory bowel disease (IBD). This study investigated associations between objective measures of disease activity and sexual function. METHODS: Adults with IBD undergoing ileocolonoscopy were prospectively recruited. Demographic, sexual function (Female Sexual Function Index and International Index of Erectile Function), disease activity (endoscopic, biomarker, and symptoms), psychological symptoms, and quality-of-life data were collected. Rates of SD and erectile dysfunction (ED) were compared between patients with active and inactive inflammation and symptoms using the Fisher’s exact test. Logistic regression examined associations between SD and ED, and disease characteristics and psychological symptoms. RESULTS: A total of 159 participants were included, 97 had Crohn’s disease and 85 were women. SD was reported in 36 of 59 and 13 of 59 sexually active women and men, respectively and ED in 22 of 59 sexually active men. Rates of SD and ED were similar between individuals with active and inactive IBD based on endoscopic indices (P > .05) and biomarkers (P > .05). Women with active IBD symptoms experienced significantly higher rates of SD (P < .05), but men did not (P > .05). Multivariable logistic regression identified that symptoms of severe depression (odds ratio, 5.77; 95% confidence interval, 1.59-20.94) were associated with SD in women, and severe anxiety (odds ratio, 15.62; 95% confidence interval, 1.74-140.23) was associated with ED in men. CONCLUSIONS: Objective measures of disease activity are not associated with SD or ED in patients with IBD. Clinicians should consider concomitant psychological symptoms contributing to the sexual health of patients with IBD. |
format | Online Article Text |
id | pubmed-10393211 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-103932112023-08-02 The Impact of Disease Activity on Sexual and Erectile Dysfunction in Patients With Inflammatory Bowel Disease Mules, Thomas C Swaminathan, Akhilesh Hirschfeld, Esther Borichevsky, Grace M Frampton, Chris M Day, Andrew S Gearry, Richard B Inflamm Bowel Dis Clinical Research BACKGROUND: Increased disease activity may be a risk factor for sexual dysfunction (SD) in patients with inflammatory bowel disease (IBD). This study investigated associations between objective measures of disease activity and sexual function. METHODS: Adults with IBD undergoing ileocolonoscopy were prospectively recruited. Demographic, sexual function (Female Sexual Function Index and International Index of Erectile Function), disease activity (endoscopic, biomarker, and symptoms), psychological symptoms, and quality-of-life data were collected. Rates of SD and erectile dysfunction (ED) were compared between patients with active and inactive inflammation and symptoms using the Fisher’s exact test. Logistic regression examined associations between SD and ED, and disease characteristics and psychological symptoms. RESULTS: A total of 159 participants were included, 97 had Crohn’s disease and 85 were women. SD was reported in 36 of 59 and 13 of 59 sexually active women and men, respectively and ED in 22 of 59 sexually active men. Rates of SD and ED were similar between individuals with active and inactive IBD based on endoscopic indices (P > .05) and biomarkers (P > .05). Women with active IBD symptoms experienced significantly higher rates of SD (P < .05), but men did not (P > .05). Multivariable logistic regression identified that symptoms of severe depression (odds ratio, 5.77; 95% confidence interval, 1.59-20.94) were associated with SD in women, and severe anxiety (odds ratio, 15.62; 95% confidence interval, 1.74-140.23) was associated with ED in men. CONCLUSIONS: Objective measures of disease activity are not associated with SD or ED in patients with IBD. Clinicians should consider concomitant psychological symptoms contributing to the sexual health of patients with IBD. Oxford University Press 2022-09-27 /pmc/articles/PMC10393211/ /pubmed/36166573 http://dx.doi.org/10.1093/ibd/izac204 Text en © 2022 Crohn’s & Colitis Foundation. Published by Oxford University Press on behalf of Crohn’s & Colitis Foundation. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Clinical Research Mules, Thomas C Swaminathan, Akhilesh Hirschfeld, Esther Borichevsky, Grace M Frampton, Chris M Day, Andrew S Gearry, Richard B The Impact of Disease Activity on Sexual and Erectile Dysfunction in Patients With Inflammatory Bowel Disease |
title | The Impact of Disease Activity on Sexual and Erectile Dysfunction in Patients With Inflammatory Bowel Disease |
title_full | The Impact of Disease Activity on Sexual and Erectile Dysfunction in Patients With Inflammatory Bowel Disease |
title_fullStr | The Impact of Disease Activity on Sexual and Erectile Dysfunction in Patients With Inflammatory Bowel Disease |
title_full_unstemmed | The Impact of Disease Activity on Sexual and Erectile Dysfunction in Patients With Inflammatory Bowel Disease |
title_short | The Impact of Disease Activity on Sexual and Erectile Dysfunction in Patients With Inflammatory Bowel Disease |
title_sort | impact of disease activity on sexual and erectile dysfunction in patients with inflammatory bowel disease |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393211/ https://www.ncbi.nlm.nih.gov/pubmed/36166573 http://dx.doi.org/10.1093/ibd/izac204 |
work_keys_str_mv | AT mulesthomasc theimpactofdiseaseactivityonsexualanderectiledysfunctioninpatientswithinflammatoryboweldisease AT swaminathanakhilesh theimpactofdiseaseactivityonsexualanderectiledysfunctioninpatientswithinflammatoryboweldisease AT hirschfeldesther theimpactofdiseaseactivityonsexualanderectiledysfunctioninpatientswithinflammatoryboweldisease AT borichevskygracem theimpactofdiseaseactivityonsexualanderectiledysfunctioninpatientswithinflammatoryboweldisease AT framptonchrism theimpactofdiseaseactivityonsexualanderectiledysfunctioninpatientswithinflammatoryboweldisease AT dayandrews theimpactofdiseaseactivityonsexualanderectiledysfunctioninpatientswithinflammatoryboweldisease AT gearryrichardb theimpactofdiseaseactivityonsexualanderectiledysfunctioninpatientswithinflammatoryboweldisease AT mulesthomasc impactofdiseaseactivityonsexualanderectiledysfunctioninpatientswithinflammatoryboweldisease AT swaminathanakhilesh impactofdiseaseactivityonsexualanderectiledysfunctioninpatientswithinflammatoryboweldisease AT hirschfeldesther impactofdiseaseactivityonsexualanderectiledysfunctioninpatientswithinflammatoryboweldisease AT borichevskygracem impactofdiseaseactivityonsexualanderectiledysfunctioninpatientswithinflammatoryboweldisease AT framptonchrism impactofdiseaseactivityonsexualanderectiledysfunctioninpatientswithinflammatoryboweldisease AT dayandrews impactofdiseaseactivityonsexualanderectiledysfunctioninpatientswithinflammatoryboweldisease AT gearryrichardb impactofdiseaseactivityonsexualanderectiledysfunctioninpatientswithinflammatoryboweldisease |