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Vascular changes in the cycling and early pregnant uterus
Uterine vascular remodeling is intrinsic to the cycling and early pregnant endometrium. Maternal regulatory factors such as ovarian hormones, VEGF, angiopoietins, Notch, and uterine natural killer cells significantly mediate these vascular changes. In the absence of pregnancy, changes in uterine ves...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393238/ https://www.ncbi.nlm.nih.gov/pubmed/37288662 http://dx.doi.org/10.1172/jci.insight.163422 |
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author | Massri, Noura Loia, Rachel Sones, Jennifer L. Arora, Ripla Douglas, Nataki C. |
author_facet | Massri, Noura Loia, Rachel Sones, Jennifer L. Arora, Ripla Douglas, Nataki C. |
author_sort | Massri, Noura |
collection | PubMed |
description | Uterine vascular remodeling is intrinsic to the cycling and early pregnant endometrium. Maternal regulatory factors such as ovarian hormones, VEGF, angiopoietins, Notch, and uterine natural killer cells significantly mediate these vascular changes. In the absence of pregnancy, changes in uterine vessel morphology and function correlate with different stages of the human menstrual cycle. During early pregnancy, vascular remodeling in rodents and humans results in decreased uterine vascular resistance and increased vascular permeability necessary for pregnancy success. Aberrations in these adaptive vascular processes contribute to increased risk of infertility, abnormal fetal growth, and/or preeclampsia. This Review comprehensively summarizes uterine vascular remodeling in the human menstrual cycle, and in the peri- and post-implantation stages in rodent species (mice and rats). |
format | Online Article Text |
id | pubmed-10393238 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Society for Clinical Investigation |
record_format | MEDLINE/PubMed |
spelling | pubmed-103932382023-08-02 Vascular changes in the cycling and early pregnant uterus Massri, Noura Loia, Rachel Sones, Jennifer L. Arora, Ripla Douglas, Nataki C. JCI Insight Review Uterine vascular remodeling is intrinsic to the cycling and early pregnant endometrium. Maternal regulatory factors such as ovarian hormones, VEGF, angiopoietins, Notch, and uterine natural killer cells significantly mediate these vascular changes. In the absence of pregnancy, changes in uterine vessel morphology and function correlate with different stages of the human menstrual cycle. During early pregnancy, vascular remodeling in rodents and humans results in decreased uterine vascular resistance and increased vascular permeability necessary for pregnancy success. Aberrations in these adaptive vascular processes contribute to increased risk of infertility, abnormal fetal growth, and/or preeclampsia. This Review comprehensively summarizes uterine vascular remodeling in the human menstrual cycle, and in the peri- and post-implantation stages in rodent species (mice and rats). American Society for Clinical Investigation 2023-06-08 /pmc/articles/PMC10393238/ /pubmed/37288662 http://dx.doi.org/10.1172/jci.insight.163422 Text en © 2023 Massri et al. https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Massri, Noura Loia, Rachel Sones, Jennifer L. Arora, Ripla Douglas, Nataki C. Vascular changes in the cycling and early pregnant uterus |
title | Vascular changes in the cycling and early pregnant uterus |
title_full | Vascular changes in the cycling and early pregnant uterus |
title_fullStr | Vascular changes in the cycling and early pregnant uterus |
title_full_unstemmed | Vascular changes in the cycling and early pregnant uterus |
title_short | Vascular changes in the cycling and early pregnant uterus |
title_sort | vascular changes in the cycling and early pregnant uterus |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393238/ https://www.ncbi.nlm.nih.gov/pubmed/37288662 http://dx.doi.org/10.1172/jci.insight.163422 |
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