Rapamycin improves social and stereotypic behavior abnormalities induced by pre‐mitotic neuronal subset specific Pten deletion

The mechanistic target of rapamycin (mTOR) pathway is a signaling system integral to neural growth and migration. In both patients and rodent models, mutations to the phosphatase and tensin homolog gene (PTEN) on chromosome 10 results in hyperactivation of the mTOR pathway, as well as seizures, inte...

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Detalles Bibliográficos
Autores principales: Narvaiz, David A., Nolan, Suzanne O., Smith, Gregory D., Holley, Andrew J., Reynolds, Conner D., Blandin, Katherine J., Nguyen, Phuoc H., Tran, Doan L. K., Lugo, Joaquin N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393422/
https://www.ncbi.nlm.nih.gov/pubmed/37376966
http://dx.doi.org/10.1111/gbb.12854

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