Heterologous mRNA-protein vaccination with Tc24 induces a robust cellular immune response against Trypanosoma cruzi, characterized by an increased level of polyfunctional CD8(+) T-cells

Tc24 is a Trypanosoma cruzi-derived flagellar protein that, when formulated with a TLR-4 agonist adjuvant, induces a balanced immune response in mice, elevating IgG2a antibody titers and IFN-γ levels. Furthermore, vaccination with the recombinant Tc24 protein can reduce parasite levels and improve s...

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Detalles Bibliográficos
Autores principales: Poveda, Cristina, Leão, Ana Carolina, Mancino, Chiara, Taraballi, Francesca, Chen, Yi-Lin, Adhikari, Rakesh, Villar, Maria Jose, Kundu, Rakhi, Nguyen, Duc M., Versteeg, Leroy, Strych, Ulrich, Hotez, Peter J., Bottazzi, Maria Elena, Pollet, Jeroen, Jones, Kathryn M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393535/
https://www.ncbi.nlm.nih.gov/pubmed/37534309
http://dx.doi.org/10.1016/j.crimmu.2023.100066

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