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Pharmacokinetics of Apixaban Among Peritoneal Dialysis Patients
RATIONALE & OBJECTIVE: The efficacy and safety profile of apixaban remains uncertain in patients receiving peritoneal dialysis (PD) despite increasing use in this population. Accordingly, we assessed the pharmacokinetics of apixaban among patients receiving PD. STUDY DESIGN: A pharmacokinetics s...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393585/ https://www.ncbi.nlm.nih.gov/pubmed/37533565 http://dx.doi.org/10.1016/j.xkme.2023.100646 |
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author | Fung, Winston Wing-Shing Cheng, Phyllis Mei-Shan Ng, Jack Kit-Chung Chan, Gordon Chun-Kau Chow, Kai Ming Li, Philip Kam-Tao Szeto, Cheuk Chun |
author_facet | Fung, Winston Wing-Shing Cheng, Phyllis Mei-Shan Ng, Jack Kit-Chung Chan, Gordon Chun-Kau Chow, Kai Ming Li, Philip Kam-Tao Szeto, Cheuk Chun |
author_sort | Fung, Winston Wing-Shing |
collection | PubMed |
description | RATIONALE & OBJECTIVE: The efficacy and safety profile of apixaban remains uncertain in patients receiving peritoneal dialysis (PD) despite increasing use in this population. Accordingly, we assessed the pharmacokinetics of apixaban among patients receiving PD. STUDY DESIGN: A pharmacokinetics study in a single center. Patients recruited received 1 week of apixaban at 2.5 mg twice a day to reach steady state. Serial blood samples were then taken before and after the last dose for pharmacokinetics analysis of apixaban. SETTING & PARTICIPANTS: Ten stable PD patients with atrial fibrillation in an outpatient setting. ANALYTICAL APPROACH/OUTCOMES: Pharmacokinetic parameters including the area under the concentration-time curve from time 0 to 12 hours after the last dose of apixaban (AUC0-12), peak concentration, trough level, time to peak apixaban concentration, half-life, and drug clearance were analyzed. RESULTS: There was a wide variation in the range of apixaban concentration across the 10 patients. The AUC(0-12) for the PD group was significantly higher than those reported previously for hemodialysis patients or healthy individuals. Three patients had a supratherapeutic peak concentration whereas 2 patients had a supratherapeutic trough level as compared with the pharmacokinetic parameter in healthy individuals taking equivalent therapeutic dosage. LIMITATIONS: Small sample size with short study duration limits the ability to ascertain the true bleeding risk and to detect any clinical outcomes. Results may be limited to Asian populations only. CONCLUSIONS: A proportion of PD patients had supratherapeutic levels even when the reduced dosage 2.5 mg twice a day was used. Given the large interindividual variation in the drug level, therapeutic drug monitoring should be done if available. Otherwise, one should start the drug at reduced doses with caution and with more frequent clinical monitoring for any signs of bleeding. |
format | Online Article Text |
id | pubmed-10393585 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-103935852023-08-02 Pharmacokinetics of Apixaban Among Peritoneal Dialysis Patients Fung, Winston Wing-Shing Cheng, Phyllis Mei-Shan Ng, Jack Kit-Chung Chan, Gordon Chun-Kau Chow, Kai Ming Li, Philip Kam-Tao Szeto, Cheuk Chun Kidney Med Original Research RATIONALE & OBJECTIVE: The efficacy and safety profile of apixaban remains uncertain in patients receiving peritoneal dialysis (PD) despite increasing use in this population. Accordingly, we assessed the pharmacokinetics of apixaban among patients receiving PD. STUDY DESIGN: A pharmacokinetics study in a single center. Patients recruited received 1 week of apixaban at 2.5 mg twice a day to reach steady state. Serial blood samples were then taken before and after the last dose for pharmacokinetics analysis of apixaban. SETTING & PARTICIPANTS: Ten stable PD patients with atrial fibrillation in an outpatient setting. ANALYTICAL APPROACH/OUTCOMES: Pharmacokinetic parameters including the area under the concentration-time curve from time 0 to 12 hours after the last dose of apixaban (AUC0-12), peak concentration, trough level, time to peak apixaban concentration, half-life, and drug clearance were analyzed. RESULTS: There was a wide variation in the range of apixaban concentration across the 10 patients. The AUC(0-12) for the PD group was significantly higher than those reported previously for hemodialysis patients or healthy individuals. Three patients had a supratherapeutic peak concentration whereas 2 patients had a supratherapeutic trough level as compared with the pharmacokinetic parameter in healthy individuals taking equivalent therapeutic dosage. LIMITATIONS: Small sample size with short study duration limits the ability to ascertain the true bleeding risk and to detect any clinical outcomes. Results may be limited to Asian populations only. CONCLUSIONS: A proportion of PD patients had supratherapeutic levels even when the reduced dosage 2.5 mg twice a day was used. Given the large interindividual variation in the drug level, therapeutic drug monitoring should be done if available. Otherwise, one should start the drug at reduced doses with caution and with more frequent clinical monitoring for any signs of bleeding. Elsevier 2023-05-02 /pmc/articles/PMC10393585/ /pubmed/37533565 http://dx.doi.org/10.1016/j.xkme.2023.100646 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Research Fung, Winston Wing-Shing Cheng, Phyllis Mei-Shan Ng, Jack Kit-Chung Chan, Gordon Chun-Kau Chow, Kai Ming Li, Philip Kam-Tao Szeto, Cheuk Chun Pharmacokinetics of Apixaban Among Peritoneal Dialysis Patients |
title | Pharmacokinetics of Apixaban Among Peritoneal Dialysis Patients |
title_full | Pharmacokinetics of Apixaban Among Peritoneal Dialysis Patients |
title_fullStr | Pharmacokinetics of Apixaban Among Peritoneal Dialysis Patients |
title_full_unstemmed | Pharmacokinetics of Apixaban Among Peritoneal Dialysis Patients |
title_short | Pharmacokinetics of Apixaban Among Peritoneal Dialysis Patients |
title_sort | pharmacokinetics of apixaban among peritoneal dialysis patients |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393585/ https://www.ncbi.nlm.nih.gov/pubmed/37533565 http://dx.doi.org/10.1016/j.xkme.2023.100646 |
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