Cargando…
Associations between laboratory variables and clinical features in patients hospitalized with COVID-19 after non-mRNA vaccination in China: A cross-sectional study
OBJECTIVES: Based on the data during the outbreak of COVID-19 in Wuxi city in China, we explored the relationship between laboratory variables and clinical features in patients hospitalized with COVID-19 after non-mRNA vaccination, and attempted to identify the significant impact of vaccination and...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393604/ https://www.ncbi.nlm.nih.gov/pubmed/37539143 http://dx.doi.org/10.1016/j.heliyon.2023.e18167 |
_version_ | 1785083196601270272 |
---|---|
author | Zhu, Dan Wu, Tie Yu, Xiao Chen, Yanxiaoqian Zhou, Tao Liu, Yating Liu, Lu Min, Zuliang |
author_facet | Zhu, Dan Wu, Tie Yu, Xiao Chen, Yanxiaoqian Zhou, Tao Liu, Yating Liu, Lu Min, Zuliang |
author_sort | Zhu, Dan |
collection | PubMed |
description | OBJECTIVES: Based on the data during the outbreak of COVID-19 in Wuxi city in China, we explored the relationship between laboratory variables and clinical features in patients hospitalized with COVID-19 after non-mRNA vaccination, and attempted to identify the significant impact of vaccination and COVID-19 infection on humans. METHODS: A retrospective observational cohort study was carried out. Patients who received non-mRNA COVID-19 vaccines and were hospitalized with COVID-19 between June 28, 2022, and July 24, 2022 were included. The correlation between different vaccine statuses, the time to negative PCR test, and biochemical parameters were investigated. RESULTS: All patients had a mild COVID-19 disease. The number of vaccine doses exerted no effects on the time to negative PCR test (P = 0.559). No differences were evident among inactivated, adenoviral-vectored, and recombinant subunit vaccines in the time to negative PCR test. Patients who just received one dose had significantly lower blood glucose levels than those who received three doses (P = 0.024), whereas two doses had no effect on blood glucose levels (one dose vs. two doses, P = 0.223; two doses vs. three doses, P = 0.457). Body temperature (β = 0.168, P = 0.011) and the percentage of lymphocytes (β = −0.219, P = 0.001) were substantially correlated with the time to COVID-19 negative PCR test. The prolonged stay was linked to a rise in GOT that fell within the usual range (P = 0.025). The percentage of lymphocytes (P = 0.007) and serum potassium (P = 0.004) were concordant with the marked change in body temperature. CONCLUSIONS: The dose and type of vaccination had no effect on the time to COVID-19 negative PCR test in patients with mild COVID-19. Comparing the first dose with the booster dose, the blood glucose levels increased within the normal range. The period at which the COVID-19 nucleic acid turned negative correlated with body temperature, the proportion of lymphocytes, GOT, and serum potassium. |
format | Online Article Text |
id | pubmed-10393604 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-103936042023-08-03 Associations between laboratory variables and clinical features in patients hospitalized with COVID-19 after non-mRNA vaccination in China: A cross-sectional study Zhu, Dan Wu, Tie Yu, Xiao Chen, Yanxiaoqian Zhou, Tao Liu, Yating Liu, Lu Min, Zuliang Heliyon Research Article OBJECTIVES: Based on the data during the outbreak of COVID-19 in Wuxi city in China, we explored the relationship between laboratory variables and clinical features in patients hospitalized with COVID-19 after non-mRNA vaccination, and attempted to identify the significant impact of vaccination and COVID-19 infection on humans. METHODS: A retrospective observational cohort study was carried out. Patients who received non-mRNA COVID-19 vaccines and were hospitalized with COVID-19 between June 28, 2022, and July 24, 2022 were included. The correlation between different vaccine statuses, the time to negative PCR test, and biochemical parameters were investigated. RESULTS: All patients had a mild COVID-19 disease. The number of vaccine doses exerted no effects on the time to negative PCR test (P = 0.559). No differences were evident among inactivated, adenoviral-vectored, and recombinant subunit vaccines in the time to negative PCR test. Patients who just received one dose had significantly lower blood glucose levels than those who received three doses (P = 0.024), whereas two doses had no effect on blood glucose levels (one dose vs. two doses, P = 0.223; two doses vs. three doses, P = 0.457). Body temperature (β = 0.168, P = 0.011) and the percentage of lymphocytes (β = −0.219, P = 0.001) were substantially correlated with the time to COVID-19 negative PCR test. The prolonged stay was linked to a rise in GOT that fell within the usual range (P = 0.025). The percentage of lymphocytes (P = 0.007) and serum potassium (P = 0.004) were concordant with the marked change in body temperature. CONCLUSIONS: The dose and type of vaccination had no effect on the time to COVID-19 negative PCR test in patients with mild COVID-19. Comparing the first dose with the booster dose, the blood glucose levels increased within the normal range. The period at which the COVID-19 nucleic acid turned negative correlated with body temperature, the proportion of lymphocytes, GOT, and serum potassium. Elsevier 2023-07-19 /pmc/articles/PMC10393604/ /pubmed/37539143 http://dx.doi.org/10.1016/j.heliyon.2023.e18167 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Article Zhu, Dan Wu, Tie Yu, Xiao Chen, Yanxiaoqian Zhou, Tao Liu, Yating Liu, Lu Min, Zuliang Associations between laboratory variables and clinical features in patients hospitalized with COVID-19 after non-mRNA vaccination in China: A cross-sectional study |
title | Associations between laboratory variables and clinical features in patients hospitalized with COVID-19 after non-mRNA vaccination in China: A cross-sectional study |
title_full | Associations between laboratory variables and clinical features in patients hospitalized with COVID-19 after non-mRNA vaccination in China: A cross-sectional study |
title_fullStr | Associations between laboratory variables and clinical features in patients hospitalized with COVID-19 after non-mRNA vaccination in China: A cross-sectional study |
title_full_unstemmed | Associations between laboratory variables and clinical features in patients hospitalized with COVID-19 after non-mRNA vaccination in China: A cross-sectional study |
title_short | Associations between laboratory variables and clinical features in patients hospitalized with COVID-19 after non-mRNA vaccination in China: A cross-sectional study |
title_sort | associations between laboratory variables and clinical features in patients hospitalized with covid-19 after non-mrna vaccination in china: a cross-sectional study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393604/ https://www.ncbi.nlm.nih.gov/pubmed/37539143 http://dx.doi.org/10.1016/j.heliyon.2023.e18167 |
work_keys_str_mv | AT zhudan associationsbetweenlaboratoryvariablesandclinicalfeaturesinpatientshospitalizedwithcovid19afternonmrnavaccinationinchinaacrosssectionalstudy AT wutie associationsbetweenlaboratoryvariablesandclinicalfeaturesinpatientshospitalizedwithcovid19afternonmrnavaccinationinchinaacrosssectionalstudy AT yuxiao associationsbetweenlaboratoryvariablesandclinicalfeaturesinpatientshospitalizedwithcovid19afternonmrnavaccinationinchinaacrosssectionalstudy AT chenyanxiaoqian associationsbetweenlaboratoryvariablesandclinicalfeaturesinpatientshospitalizedwithcovid19afternonmrnavaccinationinchinaacrosssectionalstudy AT zhoutao associationsbetweenlaboratoryvariablesandclinicalfeaturesinpatientshospitalizedwithcovid19afternonmrnavaccinationinchinaacrosssectionalstudy AT liuyating associationsbetweenlaboratoryvariablesandclinicalfeaturesinpatientshospitalizedwithcovid19afternonmrnavaccinationinchinaacrosssectionalstudy AT liulu associationsbetweenlaboratoryvariablesandclinicalfeaturesinpatientshospitalizedwithcovid19afternonmrnavaccinationinchinaacrosssectionalstudy AT minzuliang associationsbetweenlaboratoryvariablesandclinicalfeaturesinpatientshospitalizedwithcovid19afternonmrnavaccinationinchinaacrosssectionalstudy |