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Essential thrombocythemia associated with fibrosis involving bilateral renal sinuses: A case report
Essential thrombocythemia (ET) is associated with an increased risk of thrombosis and autoimmune renal involvement. We report an extremely rare case of an acute kidney injury (AKI) in the presence of bilateral renal pelvises fibrosis in a patient with a proven diagnosis of ET. A 48-year-old male pat...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393606/ https://www.ncbi.nlm.nih.gov/pubmed/37539446 http://dx.doi.org/10.1016/j.radcr.2023.07.016 |
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author | Dadkhah, Adeleh Bagheri, Seyed Morteza Rakhshankhah, Nima |
author_facet | Dadkhah, Adeleh Bagheri, Seyed Morteza Rakhshankhah, Nima |
author_sort | Dadkhah, Adeleh |
collection | PubMed |
description | Essential thrombocythemia (ET) is associated with an increased risk of thrombosis and autoimmune renal involvement. We report an extremely rare case of an acute kidney injury (AKI) in the presence of bilateral renal pelvises fibrosis in a patient with a proven diagnosis of ET. A 48-year-old male patient with a past medical history of mild chronic kidney disease and ET was admitted to our hospital with AKI. The patient discontinued his hydroxyurea treatment for the past 2 months and laboratory data showed increasing serum creatinine levels and platelet counts with increased renal sizes, severe hydrocalyx, and bilateral renal sinuses’ fibrosis in imaging. The patient started again on hydroxyurea therapy and showed improvement in all laboratory scales. ET and increased levels of platelet-derived growth factors could cause renal sinuses fibrosis and glomerulopathy. In ET patients with renal sinuses’ fibrosis and glomerulopathy, initiating cytoreductive therapy could improve the outcome. |
format | Online Article Text |
id | pubmed-10393606 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-103936062023-08-03 Essential thrombocythemia associated with fibrosis involving bilateral renal sinuses: A case report Dadkhah, Adeleh Bagheri, Seyed Morteza Rakhshankhah, Nima Radiol Case Rep Case Report Essential thrombocythemia (ET) is associated with an increased risk of thrombosis and autoimmune renal involvement. We report an extremely rare case of an acute kidney injury (AKI) in the presence of bilateral renal pelvises fibrosis in a patient with a proven diagnosis of ET. A 48-year-old male patient with a past medical history of mild chronic kidney disease and ET was admitted to our hospital with AKI. The patient discontinued his hydroxyurea treatment for the past 2 months and laboratory data showed increasing serum creatinine levels and platelet counts with increased renal sizes, severe hydrocalyx, and bilateral renal sinuses’ fibrosis in imaging. The patient started again on hydroxyurea therapy and showed improvement in all laboratory scales. ET and increased levels of platelet-derived growth factors could cause renal sinuses fibrosis and glomerulopathy. In ET patients with renal sinuses’ fibrosis and glomerulopathy, initiating cytoreductive therapy could improve the outcome. Elsevier 2023-07-25 /pmc/articles/PMC10393606/ /pubmed/37539446 http://dx.doi.org/10.1016/j.radcr.2023.07.016 Text en © 2023 The Authors. Published by Elsevier Inc. on behalf of University of Washington. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Dadkhah, Adeleh Bagheri, Seyed Morteza Rakhshankhah, Nima Essential thrombocythemia associated with fibrosis involving bilateral renal sinuses: A case report |
title | Essential thrombocythemia associated with fibrosis involving bilateral renal sinuses: A case report |
title_full | Essential thrombocythemia associated with fibrosis involving bilateral renal sinuses: A case report |
title_fullStr | Essential thrombocythemia associated with fibrosis involving bilateral renal sinuses: A case report |
title_full_unstemmed | Essential thrombocythemia associated with fibrosis involving bilateral renal sinuses: A case report |
title_short | Essential thrombocythemia associated with fibrosis involving bilateral renal sinuses: A case report |
title_sort | essential thrombocythemia associated with fibrosis involving bilateral renal sinuses: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393606/ https://www.ncbi.nlm.nih.gov/pubmed/37539446 http://dx.doi.org/10.1016/j.radcr.2023.07.016 |
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