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Drugs activating hypoxia-inducible factors correct erythropoiesis and hepcidin levels via renal EPO induction in mice

The erythroid growth factor erythropoietin (EPO) is mainly produced by the kidneys in adult mammals and induces expansion of erythroid cells and iron use for hemoglobin synthesis. The liver also produces EPO at a lower level than the kidneys. Renal and hepatic EPO production is fundamentally regulat...

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Detalles Bibliográficos
Autores principales:	Nakai, Taku, Iwamura, Yuma, Kato, Koichiro, Hirano, Ikuo, Matsumoto, Yotaro, Tomioka, Yoshihisa, Yamamoto, Masayuki, Suzuki, Norio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society of Hematology 2023
Materias:	Red Cells, Iron, and Erythropoiesis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393763/ https://www.ncbi.nlm.nih.gov/pubmed/37146271 http://dx.doi.org/10.1182/bloodadvances.2023009798

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