Cargando…
Environmental and parental risk factors for congenital solitary functioning kidney — a case–control study
BACKGROUND: The etiology of congenital solitary functioning kidney (CSFK) is largely unknown but likely includes various risk factors. We performed a case–control study to compare exposure to environmental and parental risk factors during embryonic kidney development between children with CSFK and h...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393837/ https://www.ncbi.nlm.nih.gov/pubmed/36808305 http://dx.doi.org/10.1007/s00467-023-05900-6 |
_version_ | 1785083232488783872 |
---|---|
author | Groen in ‘t Woud, Sander Roeleveld, Nel van Rooij, Iris A. L. M. Feitz, Wout F. J. Schreuder, Michiel F. van der Zanden, Loes F. M. |
author_facet | Groen in ‘t Woud, Sander Roeleveld, Nel van Rooij, Iris A. L. M. Feitz, Wout F. J. Schreuder, Michiel F. van der Zanden, Loes F. M. |
author_sort | Groen in ‘t Woud, Sander |
collection | PubMed |
description | BACKGROUND: The etiology of congenital solitary functioning kidney (CSFK) is largely unknown but likely includes various risk factors. We performed a case–control study to compare exposure to environmental and parental risk factors during embryonic kidney development between children with CSFK and healthy controls. METHODS: We included 434 children with CSFK and 1302 healthy controls from the AGORA data- and biobank matched on year of birth. Exposure to potential risk factors was investigated using parental questionnaire data. Crude and adjusted odds ratios (aORs) with 95% confidence intervals (CIs) were estimated for each potential risk factor. Multiple imputation was used to deal with missing values. Confounders for each potential risk factor were selected using directed acyclic graphs. RESULTS: Maternal stress was newly identified as a risk factor for CSFK (aOR 2.1, 95% CI 1.2–3.5). Known associations with conception using in vitro fertilization/intracytoplasmic sperm injection (aOR 1.8, 95% CI 1.0–3.2), maternal infections during pregnancy (aOR 2.5, 95% CI 1.4–4.7), smoking during pregnancy (aOR 1.4, 95% CI 1.0–2.0), and parental CAKUT (aOR 6.6, 95% CI 2.9–15.1) were confirmed, but previous associations with diabetes and obesity could not be replicated. Folic acid supplement use and younger maternal age seemed to reduce the risk of CSFK (aORs 0.7, 95% CI 0.5–1.0, and 0.8, 95% CI 0.6–1.0, respectively). CONCLUSIONS: Environmental and parental risk factors are likely to be involved in the development of CSFK and future studies should combine genetic, environmental, and gene-environment interaction analyses. Women wanting to become pregnant should consider optimizing their health and lifestyle. GRAPHICAL ABSTRACT: [Figure: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00467-023-05900-6. |
format | Online Article Text |
id | pubmed-10393837 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-103938372023-08-03 Environmental and parental risk factors for congenital solitary functioning kidney — a case–control study Groen in ‘t Woud, Sander Roeleveld, Nel van Rooij, Iris A. L. M. Feitz, Wout F. J. Schreuder, Michiel F. van der Zanden, Loes F. M. Pediatr Nephrol Original Article BACKGROUND: The etiology of congenital solitary functioning kidney (CSFK) is largely unknown but likely includes various risk factors. We performed a case–control study to compare exposure to environmental and parental risk factors during embryonic kidney development between children with CSFK and healthy controls. METHODS: We included 434 children with CSFK and 1302 healthy controls from the AGORA data- and biobank matched on year of birth. Exposure to potential risk factors was investigated using parental questionnaire data. Crude and adjusted odds ratios (aORs) with 95% confidence intervals (CIs) were estimated for each potential risk factor. Multiple imputation was used to deal with missing values. Confounders for each potential risk factor were selected using directed acyclic graphs. RESULTS: Maternal stress was newly identified as a risk factor for CSFK (aOR 2.1, 95% CI 1.2–3.5). Known associations with conception using in vitro fertilization/intracytoplasmic sperm injection (aOR 1.8, 95% CI 1.0–3.2), maternal infections during pregnancy (aOR 2.5, 95% CI 1.4–4.7), smoking during pregnancy (aOR 1.4, 95% CI 1.0–2.0), and parental CAKUT (aOR 6.6, 95% CI 2.9–15.1) were confirmed, but previous associations with diabetes and obesity could not be replicated. Folic acid supplement use and younger maternal age seemed to reduce the risk of CSFK (aORs 0.7, 95% CI 0.5–1.0, and 0.8, 95% CI 0.6–1.0, respectively). CONCLUSIONS: Environmental and parental risk factors are likely to be involved in the development of CSFK and future studies should combine genetic, environmental, and gene-environment interaction analyses. Women wanting to become pregnant should consider optimizing their health and lifestyle. GRAPHICAL ABSTRACT: [Figure: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00467-023-05900-6. Springer Berlin Heidelberg 2023-02-20 2023 /pmc/articles/PMC10393837/ /pubmed/36808305 http://dx.doi.org/10.1007/s00467-023-05900-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Groen in ‘t Woud, Sander Roeleveld, Nel van Rooij, Iris A. L. M. Feitz, Wout F. J. Schreuder, Michiel F. van der Zanden, Loes F. M. Environmental and parental risk factors for congenital solitary functioning kidney — a case–control study |
title | Environmental and parental risk factors for congenital solitary functioning kidney — a case–control study |
title_full | Environmental and parental risk factors for congenital solitary functioning kidney — a case–control study |
title_fullStr | Environmental and parental risk factors for congenital solitary functioning kidney — a case–control study |
title_full_unstemmed | Environmental and parental risk factors for congenital solitary functioning kidney — a case–control study |
title_short | Environmental and parental risk factors for congenital solitary functioning kidney — a case–control study |
title_sort | environmental and parental risk factors for congenital solitary functioning kidney — a case–control study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393837/ https://www.ncbi.nlm.nih.gov/pubmed/36808305 http://dx.doi.org/10.1007/s00467-023-05900-6 |
work_keys_str_mv | AT groenintwoudsander environmentalandparentalriskfactorsforcongenitalsolitaryfunctioningkidneyacasecontrolstudy AT roeleveldnel environmentalandparentalriskfactorsforcongenitalsolitaryfunctioningkidneyacasecontrolstudy AT vanrooijirisalm environmentalandparentalriskfactorsforcongenitalsolitaryfunctioningkidneyacasecontrolstudy AT feitzwoutfj environmentalandparentalriskfactorsforcongenitalsolitaryfunctioningkidneyacasecontrolstudy AT schreudermichielf environmentalandparentalriskfactorsforcongenitalsolitaryfunctioningkidneyacasecontrolstudy AT vanderzandenloesfm environmentalandparentalriskfactorsforcongenitalsolitaryfunctioningkidneyacasecontrolstudy AT environmentalandparentalriskfactorsforcongenitalsolitaryfunctioningkidneyacasecontrolstudy |