Advanced cryopreservation engineering strategies: the critical step to utilize stem cell products

With the rapid development of stem cell-related therapies and regenerative medicine, the clinical application of stem cell products is on the rise. However, ensuring the effectiveness of these products after storage and transportation remains a challenge in the transformation to clinical trials. Cry...

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Detalles Bibliográficos
Autores principales: Wang, Xiaohu, Wang, Enyu, Zhao, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393932/
https://www.ncbi.nlm.nih.gov/pubmed/37528321
http://dx.doi.org/10.1186/s13619-023-00173-8
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author Wang, Xiaohu
Wang, Enyu
Zhao, Gang
author_facet Wang, Xiaohu
Wang, Enyu
Zhao, Gang
author_sort Wang, Xiaohu
collection PubMed
description With the rapid development of stem cell-related therapies and regenerative medicine, the clinical application of stem cell products is on the rise. However, ensuring the effectiveness of these products after storage and transportation remains a challenge in the transformation to clinical trials. Cryopreservation technology allows for the long-term storage of cells while ensuring viability, making it a top priority for stem cell preservation. The field of cryopreservation-related engineering technologies is thriving, and this review provides an overview of the background and basic principles of cryopreservation. It then delves into the main bioengineering technologies and strategies used in cryopreservation, including photothermal and electromagnetic rewarming, microencapsulation, and synergetic ice inhibition. Finally, the current challenges and future prospects in the field of efficient cryopreservation of stem cells are summarized and discussed.
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spelling pubmed-103939322023-08-03 Advanced cryopreservation engineering strategies: the critical step to utilize stem cell products Wang, Xiaohu Wang, Enyu Zhao, Gang Cell Regen Review With the rapid development of stem cell-related therapies and regenerative medicine, the clinical application of stem cell products is on the rise. However, ensuring the effectiveness of these products after storage and transportation remains a challenge in the transformation to clinical trials. Cryopreservation technology allows for the long-term storage of cells while ensuring viability, making it a top priority for stem cell preservation. The field of cryopreservation-related engineering technologies is thriving, and this review provides an overview of the background and basic principles of cryopreservation. It then delves into the main bioengineering technologies and strategies used in cryopreservation, including photothermal and electromagnetic rewarming, microencapsulation, and synergetic ice inhibition. Finally, the current challenges and future prospects in the field of efficient cryopreservation of stem cells are summarized and discussed. Springer Nature Singapore 2023-08-02 /pmc/articles/PMC10393932/ /pubmed/37528321 http://dx.doi.org/10.1186/s13619-023-00173-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Wang, Xiaohu
Wang, Enyu
Zhao, Gang
Advanced cryopreservation engineering strategies: the critical step to utilize stem cell products
title Advanced cryopreservation engineering strategies: the critical step to utilize stem cell products
title_full Advanced cryopreservation engineering strategies: the critical step to utilize stem cell products
title_fullStr Advanced cryopreservation engineering strategies: the critical step to utilize stem cell products
title_full_unstemmed Advanced cryopreservation engineering strategies: the critical step to utilize stem cell products
title_short Advanced cryopreservation engineering strategies: the critical step to utilize stem cell products
title_sort advanced cryopreservation engineering strategies: the critical step to utilize stem cell products
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393932/
https://www.ncbi.nlm.nih.gov/pubmed/37528321
http://dx.doi.org/10.1186/s13619-023-00173-8
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