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TXNIP: A key protein in the cellular stress response pathway and a potential therapeutic target
Thioredoxin-interacting protein (TXNIP), which is also known as thioredoxin-binding protein 2 (TBP2), directly interacts with the major antioxidant protein thioredoxin (TRX) and inhibits its antioxidant function and expression. However, recent studies have demonstrated that TXNIP is a multifunctiona...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393958/ https://www.ncbi.nlm.nih.gov/pubmed/37394581 http://dx.doi.org/10.1038/s12276-023-01019-8 |
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author | Choi, Eui-Hwan Park, Sun-Ji |
author_facet | Choi, Eui-Hwan Park, Sun-Ji |
author_sort | Choi, Eui-Hwan |
collection | PubMed |
description | Thioredoxin-interacting protein (TXNIP), which is also known as thioredoxin-binding protein 2 (TBP2), directly interacts with the major antioxidant protein thioredoxin (TRX) and inhibits its antioxidant function and expression. However, recent studies have demonstrated that TXNIP is a multifunctional protein with functions beyond increasing intracellular oxidative stress. TXNIP activates endoplasmic reticulum (ER) stress-mediated nucleotide-binding oligomerization domain (NOD)-like receptor protein-3 (NLRP3) inflammasome complex formation, triggers mitochondrial stress-induced apoptosis, and stimulates inflammatory cell death (pyroptosis). These newly discovered functions of TXNIP highlight its role in disease development, especially in response to several cellular stress factors. In this review, we provide an overview of the multiple functions of TXNIP in pathological conditions and summarize its involvement in various diseases, such as diabetes, chronic kidney disease, and neurodegenerative diseases. We also discuss the potential of TXNIP as a therapeutic target and TXNIP inhibitors as novel therapeutic drugs for treating these diseases. |
format | Online Article Text |
id | pubmed-10393958 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-103939582023-08-03 TXNIP: A key protein in the cellular stress response pathway and a potential therapeutic target Choi, Eui-Hwan Park, Sun-Ji Exp Mol Med Review Article Thioredoxin-interacting protein (TXNIP), which is also known as thioredoxin-binding protein 2 (TBP2), directly interacts with the major antioxidant protein thioredoxin (TRX) and inhibits its antioxidant function and expression. However, recent studies have demonstrated that TXNIP is a multifunctional protein with functions beyond increasing intracellular oxidative stress. TXNIP activates endoplasmic reticulum (ER) stress-mediated nucleotide-binding oligomerization domain (NOD)-like receptor protein-3 (NLRP3) inflammasome complex formation, triggers mitochondrial stress-induced apoptosis, and stimulates inflammatory cell death (pyroptosis). These newly discovered functions of TXNIP highlight its role in disease development, especially in response to several cellular stress factors. In this review, we provide an overview of the multiple functions of TXNIP in pathological conditions and summarize its involvement in various diseases, such as diabetes, chronic kidney disease, and neurodegenerative diseases. We also discuss the potential of TXNIP as a therapeutic target and TXNIP inhibitors as novel therapeutic drugs for treating these diseases. Nature Publishing Group UK 2023-07-03 /pmc/articles/PMC10393958/ /pubmed/37394581 http://dx.doi.org/10.1038/s12276-023-01019-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Article Choi, Eui-Hwan Park, Sun-Ji TXNIP: A key protein in the cellular stress response pathway and a potential therapeutic target |
title | TXNIP: A key protein in the cellular stress response pathway and a potential therapeutic target |
title_full | TXNIP: A key protein in the cellular stress response pathway and a potential therapeutic target |
title_fullStr | TXNIP: A key protein in the cellular stress response pathway and a potential therapeutic target |
title_full_unstemmed | TXNIP: A key protein in the cellular stress response pathway and a potential therapeutic target |
title_short | TXNIP: A key protein in the cellular stress response pathway and a potential therapeutic target |
title_sort | txnip: a key protein in the cellular stress response pathway and a potential therapeutic target |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393958/ https://www.ncbi.nlm.nih.gov/pubmed/37394581 http://dx.doi.org/10.1038/s12276-023-01019-8 |
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