CD38/ADP-ribose/TRPM2-mediated nuclear Ca(2+) signaling is essential for hepatic gluconeogenesis in fasting and diabetes

Hepatic glucose production by glucagon is crucial for glucose homeostasis during fasting, yet the underlying mechanisms remain incompletely delineated. Although CD38 has been detected in the nucleus, its function in this compartment is unknown. Here, we demonstrate that nuclear CD38 (nCD38) controls...

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Detalles Bibliográficos
Autores principales: Rah, So-Young, Joe, Yeonsoo, Park, Jeongmin, Ryter, Stefan W., Park, Chansu, Chung, Hun Taeg, Kim, Uh-Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393965/
https://www.ncbi.nlm.nih.gov/pubmed/37394593
http://dx.doi.org/10.1038/s12276-023-01034-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393965/
https://www.ncbi.nlm.nih.gov/pubmed/37394593
http://dx.doi.org/10.1038/s12276-023-01034-9

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