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A case of disseminated M. bovis bacillus Calmette-Guérin (BCG) disease after one month of BCG bladder infusion therapy and analysis of 77 cases of suspected BCG infection in Japan, 2017–2022

Bacillus Calmette-Guerin (BCG) intravesical injections are used as adjuvant therapy for superficial bladder cancer. We report a case of a 78-year-old man who developed disseminated M. bovis BCG disease mimicking miliary tuberculosis early after BCG intravesical infusion. He started coughing after re...

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Autores principales: Nishimura, Masashi, Okumura, Masao, Takemasa, Takii, Yoshiyama, Takashi, Tanaka, Yoshiaki, Saotome, Mikio, Ohta, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393993/
https://www.ncbi.nlm.nih.gov/pubmed/37538979
http://dx.doi.org/10.1016/j.rmcr.2023.101902
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author Nishimura, Masashi
Okumura, Masao
Takemasa, Takii
Yoshiyama, Takashi
Tanaka, Yoshiaki
Saotome, Mikio
Ohta, Ken
author_facet Nishimura, Masashi
Okumura, Masao
Takemasa, Takii
Yoshiyama, Takashi
Tanaka, Yoshiaki
Saotome, Mikio
Ohta, Ken
author_sort Nishimura, Masashi
collection PubMed
description Bacillus Calmette-Guerin (BCG) intravesical injections are used as adjuvant therapy for superficial bladder cancer. We report a case of a 78-year-old man who developed disseminated M. bovis BCG disease mimicking miliary tuberculosis early after BCG intravesical infusion. He started coughing after receiving three rounds of BCG for superficial bladder tumors, following transurethral resection of the tumors, approximately one month after initiation. Computerized tomography (CT) images showed diffuse nodular shadows in the bilateral lung fields with a random pattern. Consequently, disseminated BCG disease was diagnosed. Treatment with isoniazid, rifampicin, and ethambutol was initiated. Nine months after initiating treatment, CT showed the disappearance of the miliary shadows. We also discussed 77 cases of suspected BCG infection and the requests for Mycobacterium bovis BCG identification at our institution from 2017 to October 2022. Of these, 76 cases were M. bovis BCG, and 1 case was M. tuberculosis. Since M. tuberculosis can be identified in some patients with suspected BCG infection, it is crucial to distinguish between the two based on pathogenicity.
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spelling pubmed-103939932023-08-03 A case of disseminated M. bovis bacillus Calmette-Guérin (BCG) disease after one month of BCG bladder infusion therapy and analysis of 77 cases of suspected BCG infection in Japan, 2017–2022 Nishimura, Masashi Okumura, Masao Takemasa, Takii Yoshiyama, Takashi Tanaka, Yoshiaki Saotome, Mikio Ohta, Ken Respir Med Case Rep Case Report Bacillus Calmette-Guerin (BCG) intravesical injections are used as adjuvant therapy for superficial bladder cancer. We report a case of a 78-year-old man who developed disseminated M. bovis BCG disease mimicking miliary tuberculosis early after BCG intravesical infusion. He started coughing after receiving three rounds of BCG for superficial bladder tumors, following transurethral resection of the tumors, approximately one month after initiation. Computerized tomography (CT) images showed diffuse nodular shadows in the bilateral lung fields with a random pattern. Consequently, disseminated BCG disease was diagnosed. Treatment with isoniazid, rifampicin, and ethambutol was initiated. Nine months after initiating treatment, CT showed the disappearance of the miliary shadows. We also discussed 77 cases of suspected BCG infection and the requests for Mycobacterium bovis BCG identification at our institution from 2017 to October 2022. Of these, 76 cases were M. bovis BCG, and 1 case was M. tuberculosis. Since M. tuberculosis can be identified in some patients with suspected BCG infection, it is crucial to distinguish between the two based on pathogenicity. Elsevier 2023-07-22 /pmc/articles/PMC10393993/ /pubmed/37538979 http://dx.doi.org/10.1016/j.rmcr.2023.101902 Text en © 2023 The Authors. Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Nishimura, Masashi
Okumura, Masao
Takemasa, Takii
Yoshiyama, Takashi
Tanaka, Yoshiaki
Saotome, Mikio
Ohta, Ken
A case of disseminated M. bovis bacillus Calmette-Guérin (BCG) disease after one month of BCG bladder infusion therapy and analysis of 77 cases of suspected BCG infection in Japan, 2017–2022
title A case of disseminated M. bovis bacillus Calmette-Guérin (BCG) disease after one month of BCG bladder infusion therapy and analysis of 77 cases of suspected BCG infection in Japan, 2017–2022
title_full A case of disseminated M. bovis bacillus Calmette-Guérin (BCG) disease after one month of BCG bladder infusion therapy and analysis of 77 cases of suspected BCG infection in Japan, 2017–2022
title_fullStr A case of disseminated M. bovis bacillus Calmette-Guérin (BCG) disease after one month of BCG bladder infusion therapy and analysis of 77 cases of suspected BCG infection in Japan, 2017–2022
title_full_unstemmed A case of disseminated M. bovis bacillus Calmette-Guérin (BCG) disease after one month of BCG bladder infusion therapy and analysis of 77 cases of suspected BCG infection in Japan, 2017–2022
title_short A case of disseminated M. bovis bacillus Calmette-Guérin (BCG) disease after one month of BCG bladder infusion therapy and analysis of 77 cases of suspected BCG infection in Japan, 2017–2022
title_sort case of disseminated m. bovis bacillus calmette-guérin (bcg) disease after one month of bcg bladder infusion therapy and analysis of 77 cases of suspected bcg infection in japan, 2017–2022
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10393993/
https://www.ncbi.nlm.nih.gov/pubmed/37538979
http://dx.doi.org/10.1016/j.rmcr.2023.101902
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