Mitochonic acid 5 attenuates age-related neuromuscular dysfunction associated with mitochondrial Ca(2+) overload in Caenorhabditis elegans

Mitochonic acid-5 ameliorates the pathophysiology of human mitochondrial-disease fibroblasts and Caenorhabditis elegans Duchenne muscular dystrophy and Parkinson’s disease models. Here, we found that 10 μM MA-5 attenuates the age-related decline in motor performance, loss of muscle mitochondria, and...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, XinTong, Seida, Miku, Abe, Takaaki, Higashitani, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394014/
https://www.ncbi.nlm.nih.gov/pubmed/37528117
http://dx.doi.org/10.1038/s41514-023-00116-2
_version_ 1785083272975351808
author Wu, XinTong
Seida, Miku
Abe, Takaaki
Higashitani, Atsushi
author_facet Wu, XinTong
Seida, Miku
Abe, Takaaki
Higashitani, Atsushi
author_sort Wu, XinTong
collection PubMed
description Mitochonic acid-5 ameliorates the pathophysiology of human mitochondrial-disease fibroblasts and Caenorhabditis elegans Duchenne muscular dystrophy and Parkinson’s disease models. Here, we found that 10 μM MA-5 attenuates the age-related decline in motor performance, loss of muscle mitochondria, and degeneration of dopaminergic neurons associated with mitochondrial Ca(2+) overload in C. elegans. These findings suggest that MA-5 may act as an anti-aging agent against a wide range of neuromuscular dysfunctions in metazoans.
format Online
Article
Text
id pubmed-10394014
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-103940142023-08-03 Mitochonic acid 5 attenuates age-related neuromuscular dysfunction associated with mitochondrial Ca(2+) overload in Caenorhabditis elegans Wu, XinTong Seida, Miku Abe, Takaaki Higashitani, Atsushi NPJ Aging Brief Communication Mitochonic acid-5 ameliorates the pathophysiology of human mitochondrial-disease fibroblasts and Caenorhabditis elegans Duchenne muscular dystrophy and Parkinson’s disease models. Here, we found that 10 μM MA-5 attenuates the age-related decline in motor performance, loss of muscle mitochondria, and degeneration of dopaminergic neurons associated with mitochondrial Ca(2+) overload in C. elegans. These findings suggest that MA-5 may act as an anti-aging agent against a wide range of neuromuscular dysfunctions in metazoans. Nature Publishing Group UK 2023-08-01 /pmc/articles/PMC10394014/ /pubmed/37528117 http://dx.doi.org/10.1038/s41514-023-00116-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Wu, XinTong
Seida, Miku
Abe, Takaaki
Higashitani, Atsushi
Mitochonic acid 5 attenuates age-related neuromuscular dysfunction associated with mitochondrial Ca(2+) overload in Caenorhabditis elegans
title Mitochonic acid 5 attenuates age-related neuromuscular dysfunction associated with mitochondrial Ca(2+) overload in Caenorhabditis elegans
title_full Mitochonic acid 5 attenuates age-related neuromuscular dysfunction associated with mitochondrial Ca(2+) overload in Caenorhabditis elegans
title_fullStr Mitochonic acid 5 attenuates age-related neuromuscular dysfunction associated with mitochondrial Ca(2+) overload in Caenorhabditis elegans
title_full_unstemmed Mitochonic acid 5 attenuates age-related neuromuscular dysfunction associated with mitochondrial Ca(2+) overload in Caenorhabditis elegans
title_short Mitochonic acid 5 attenuates age-related neuromuscular dysfunction associated with mitochondrial Ca(2+) overload in Caenorhabditis elegans
title_sort mitochonic acid 5 attenuates age-related neuromuscular dysfunction associated with mitochondrial ca(2+) overload in caenorhabditis elegans
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394014/
https://www.ncbi.nlm.nih.gov/pubmed/37528117
http://dx.doi.org/10.1038/s41514-023-00116-2
work_keys_str_mv AT wuxintong mitochonicacid5attenuatesagerelatedneuromusculardysfunctionassociatedwithmitochondrialca2overloadincaenorhabditiselegans
AT seidamiku mitochonicacid5attenuatesagerelatedneuromusculardysfunctionassociatedwithmitochondrialca2overloadincaenorhabditiselegans
AT abetakaaki mitochonicacid5attenuatesagerelatedneuromusculardysfunctionassociatedwithmitochondrialca2overloadincaenorhabditiselegans
AT higashitaniatsushi mitochonicacid5attenuatesagerelatedneuromusculardysfunctionassociatedwithmitochondrialca2overloadincaenorhabditiselegans

Ejemplares similares