Cargando…

Mitochonic acid 5 attenuates age-related neuromuscular dysfunction associated with mitochondrial Ca(2+) overload in Caenorhabditis elegans

Mitochonic acid-5 ameliorates the pathophysiology of human mitochondrial-disease fibroblasts and Caenorhabditis elegans Duchenne muscular dystrophy and Parkinson’s disease models. Here, we found that 10 μM MA-5 attenuates the age-related decline in motor performance, loss of muscle mitochondria, and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, XinTong, Seida, Miku, Abe, Takaaki, Higashitani, Atsushi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Brief Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394014/ https://www.ncbi.nlm.nih.gov/pubmed/37528117 http://dx.doi.org/10.1038/s41514-023-00116-2

Ejemplares similares

Mitochonic Acid 5 Improves Duchenne Muscular Dystrophy and Parkinson’s Disease Model of Caenorhabditis elegans
por: Wu, Xintong, et al.
Publicado: (2022)

Mitochondrial dysfunction causes Ca(2+) overload and ECM degradation–mediated muscle damage in C. elegans
por: Sudevan, Surabhi, et al.
Publicado: (2019)

Fluid dynamics alter Caenorhabditis elegans body length via TGF-β/DBL-1 neuromuscular signaling
por: Harada, Shunsuke, et al.
Publicado: (2016)

Heat-Induced Calcium Leakage Causes Mitochondrial Damage in Caenorhabditis elegans Body-Wall Muscles
por: Momma, Kenta, et al.
Publicado: (2017)

Mitochonic Acid 5 (MA-5) Facilitates ATP Synthase Oligomerization and Cell Survival in Various Mitochondrial Diseases
por: Matsuhashi, Tetsuro, et al.
Publicado: (2017)

Caenorhabditis elegans in microgravity: An omics perspective
por: Scott, Amanda, et al.
Publicado: (2023)

Mitochonic acid 5 regulates mitofusin 2 to protect microglia
por: Tan, Jian, et al.
Publicado: (2021)

Ultrafast endocytosis at Caenorhabditis elegans neuromuscular junctions
por: Watanabe, Shigeki, et al.
Publicado: (2013)

222 nm far-UVC efficiently introduces nerve damage in Caenorhabditis elegans
por: Yoshiyama, Kaoru Okamoto, et al.
Publicado: (2023)

Mitochondrial Dysfunction Confers Resistance to Multiple Drugs in Caenorhabditis elegans
por: Zubovych, Iryna O., et al.
Publicado: (2010)

High-glucose diets induce mitochondrial dysfunction in Caenorhabditis elegans
por: Alcántar-Fernández, Jonathan, et al.
Publicado: (2019)

Insights into cisplatin-induced neurotoxicity and mitochondrial dysfunction in Caenorhabditis elegans
por: Martínez-Fernández, Carmen, et al.
Publicado: (2022)

The Effectiveness of RNAi in Caenorhabditis elegans Is Maintained during Spaceflight
por: Etheridge, Timothy, et al.
Publicado: (2011)

Caenorhabditis elegans Neuromuscular Junction: GABA Receptors and Ivermectin Action
por: Hernando, Guillermina, et al.
Publicado: (2014)

A Behavioral Survey of the Effects of Kavalactones on Caenorhabditis elegans Neuromuscular Transmission
por: Kautu, Bwarenaba B, et al.
Publicado: (2017)

Sexually Dimorphic Neurotransmitter Release at the Neuromuscular Junction in Adult Caenorhabditis elegans
por: Yan, Zhenzhen, et al.
Publicado: (2022)

PXF-1 promotes synapse development at the neuromuscular junction in Caenorhabditis elegans
por: Lamb, Reagan, et al.
Publicado: (2022)

Microgravity elicits reproducible alterations in cytoskeletal and metabolic gene and protein expression in space-flown Caenorhabditis elegans
por: Higashibata, Akira, et al.
Publicado: (2016)

Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans
por: Honda, Yoko, et al.
Publicado: (2012)

Comparative Analysis of Muscle Atrophy During Spaceflight, Nutritional Deficiency and Disuse in the Nematode Caenorhabditis elegans
por: Kim, Ban-seok, et al.
Publicado: (2023)

Ca(2+)-dependent Muscle Dysfunction Caused by Mutation of the Caenorhabditis elegans Troponin T-1 Gene
por: McArdle, Kristen, et al.
Publicado: (1998)

Iron overload and neurodegenerative diseases: What can we learn from Caenorhabditis elegans?
por: Martins, Airton C, et al.
Publicado: (2022)

Genome-wide analysis links emerin to neuromuscular junction activity in Caenorhabditis elegans
por: González-Aguilera, Cristina, et al.
Publicado: (2014)

LIN-12/Notch Regulates GABA Signaling at the Caenorhabditis elegans Neuromuscular Junction
por: Sorkaç, Altar, et al.
Publicado: (2018)

Presenilin mutations deregulate mitochondrial Ca(2+) homeostasis and metabolic activity causing neurodegeneration in Caenorhabditis elegans
por: Sarasija, Shaarika, et al.
Publicado: (2018)

Relationship Between Mitochondrial Electron Transport Chain Dysfunction, Development, and Life Extension in Caenorhabditis elegans
por: Rea, Shane L, et al.
Publicado: (2007)

Meiotic dysfunction accelerates somatic aging in Caenorhabditis elegans
por: Loose, Julia A., et al.
Publicado: (2022)

Exposure to Mitochondrial Genotoxins and Dopaminergic Neurodegeneration in Caenorhabditis elegans
por: González-Hunt, Claudia P., et al.
Publicado: (2014)

Kinetics and specificity of paternal mitochondrial elimination in Caenorhabditis elegans
por: Wang, Yang, et al.
Publicado: (2016)

Allele-specific mitochondrial stress induced by Multiple Mitochondrial Dysfunctions Syndrome 1 pathogenic mutations modeled in Caenorhabditis elegans
por: Kropp, Peter A., et al.
Publicado: (2021)

Regulation of WNT Signaling at the Neuromuscular Junction by the Immunoglobulin Superfamily Protein RIG-3 in Caenorhabditis elegans
por: Pandey, Pratima, et al.
Publicado: (2017)

Cholinergic signaling at the body wall neuromuscular junction distally inhibits feeding behavior in Caenorhabditis elegans
por: Izquierdo, Patricia G., et al.
Publicado: (2021)

Caenorhabditis Elegans
Publicado: (2000)

Correction: Relationship Between Mitochondrial Electron Transport Chain Dysfunction, Development, and Life Extension in Caenorhabditis elegans
por: Rea, Shane L, et al.
Publicado: (2008)

Correction: Relationship Between Mitochondrial Electron Transport Chain Dysfunction, Development, and Life Extension in Caenorhabditis elegan
por: Rea, Shane L, et al.
Publicado: (2008)

Correction: Relationship Between Mitochondrial Electron Transport Chain Dysfunction, Development and Life Extension in Caenorhabditis elegans
por: Rea, Shane L, et al.
Publicado: (2008)

Role of Presenilin in Mitochondrial Oxidative Stress and Neurodegeneration in Caenorhabditis elegans
por: Sarasija, Shaarika, et al.
Publicado: (2018)

Disruption of mitochondrial dynamics affects behaviour and lifespan in Caenorhabditis elegans
por: Byrne, Joseph J., et al.
Publicado: (2019)

Flavonoids mitigate neurodegeneration in aged Caenorhabditis elegans by mitochondrial uncoupling
por: Cho, Injeong, et al.
Publicado: (2020)

The C-terminal of CASY-1/Calsyntenin regulates GABAergic synaptic transmission at the Caenorhabditis elegans neuromuscular junction
por: Thapliyal, Shruti, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_7i08o9vhvpvpuhqebajajk9t0m