TRIB1 confers therapeutic resistance in GBM cells by activating the ERK and Akt pathways

GBM (Glioblastoma) is the most lethal CNS (Central nervous system) tumor in adults, which inevitably develops resistance to standard treatments leading to recurrence and mortality. TRIB1 is a serine/threonine pseudokinase which functions as a scaffold platform that initiates degradation of its subst...

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Detalles Bibliográficos
Autores principales: Singh, Karnika, Han, Chunhua, Fleming, Jessica L., Becker, Aline P., McElroy, Joseph, Cui, Tiantian, Johnson, Benjamin, Kumar, Ashok, Sebastian, Ebin, Showalter, Christian A., Schrock, Morgan S., Summers, Matthew K., Becker, Valesio, Tong, Zhen-yue, Meng, Xiaomei, Manring, Heather R., Venere, Monica, Bell, Erica H., Robe, Pierre A., Grosu, A. L., Haque, S. Jaharul, Chakravarti, Arnab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394028/
https://www.ncbi.nlm.nih.gov/pubmed/37528172
http://dx.doi.org/10.1038/s41598-023-32983-w

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