HDAC1 and HDAC6 are essential for driving growth in IDH1 mutant glioma

Low-grade and secondary high-grade gliomas frequently contain mutations in the IDH1 or IDH2 metabolic enzymes that are hypothesized to drive tumorigenesis by inhibiting many of the chromatin-regulating enzymes that regulate DNA structure. Histone deacetylase inhibitors are promising anti-cancer agen...

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Detalles Bibliográficos
Autores principales: Garrett, Matthew C., Albano, Rebecca, Carnwath, Troy, Elahi, Lubayna, Behrmann, Catherine A., Pemberton, Merissa, Woo, Daniel, O’Brien, Eric, VanCauwenbergh, Brett, Perentesis, John, Shah, Sanjit, Hagan, Matthew, Kendler, Ady, Zhao, Chuntao, Paranjpe, Aditi, Roskin, Krishna, Kornblum, Harley, Plas, David R., Lu, Q. Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394035/
https://www.ncbi.nlm.nih.gov/pubmed/37528157
http://dx.doi.org/10.1038/s41598-023-33889-3

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