Genetic inhibition of CARD9 accelerates the development of atherosclerosis in mice through CD36 dependent-defective autophagy

Caspase recruitment-domain containing protein 9 (CARD9) is a key signaling pathway in macrophages but its role in atherosclerosis is still poorly understood. Global deletion of Card9 in Apoe(-/-) mice as well as hematopoietic deletion in Ldlr(-/-) mice increases atherosclerosis. The acceleration of...

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Detalles Bibliográficos
Autores principales: Zhang, Yujiao, Vandestienne, Marie, Lavillegrand, Jean-Rémi, Joffre, Jeremie, Santos-Zas, Icia, Lavelle, Aonghus, Zhong, Xiaodan, Le Goff, Wilfried, Guérin, Maryse, Al-Rifai, Rida, Laurans, Ludivine, Bruneval, Patrick, Guérin, Coralie, Diedisheim, Marc, Migaud, Melanie, Puel, Anne, Lanternier, Fanny, Casanova, Jean-Laurent, Cochain, Clément, Zernecke, Alma, Saliba, Antoine-Emmanuel, Mokry, Michal, Silvestre, Jean-Sebastien, Tedgui, Alain, Mallat, Ziad, Taleb, Soraya, Lenoir, Olivia, Vindis, Cécile, Camus, Stéphane M., Sokol, Harry, Ait-Oufella, Hafid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394049/
https://www.ncbi.nlm.nih.gov/pubmed/37528097
http://dx.doi.org/10.1038/s41467-023-40216-x

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