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Effects of neutron radiation generated in deep space-like environments on food resources

The impact of deep space cosmic rays on food resources is as important as the risks of cosmic rays to the human body. This study demonstrates the potential for neutrons as secondary radiation in deep space spacecraft to cause meat activation and oxidative modification of proteins and lipids. We cond...

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Autores principales: Hatsuda, Machiko, Kawasaki, Hiroaki, Shigenaga, Ayako, Taketani, Atsushi, Takanashi, Takaoki, Wakabayashi, Yasuo, Otake, Yoshie, Kamata, Yayoi, Ichinose, Akari, Nishioka, Honoka, Kimura, Hayato, Koganei, Yumi, Komoriya, Shiomi, Sakai, Miyu, Hamano, Yui, Yoshida, Maria, Yamakura, Fumiyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394055/
https://www.ncbi.nlm.nih.gov/pubmed/37528144
http://dx.doi.org/10.1038/s41598-023-38990-1
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author Hatsuda, Machiko
Kawasaki, Hiroaki
Shigenaga, Ayako
Taketani, Atsushi
Takanashi, Takaoki
Wakabayashi, Yasuo
Otake, Yoshie
Kamata, Yayoi
Ichinose, Akari
Nishioka, Honoka
Kimura, Hayato
Koganei, Yumi
Komoriya, Shiomi
Sakai, Miyu
Hamano, Yui
Yoshida, Maria
Yamakura, Fumiyuki
author_facet Hatsuda, Machiko
Kawasaki, Hiroaki
Shigenaga, Ayako
Taketani, Atsushi
Takanashi, Takaoki
Wakabayashi, Yasuo
Otake, Yoshie
Kamata, Yayoi
Ichinose, Akari
Nishioka, Honoka
Kimura, Hayato
Koganei, Yumi
Komoriya, Shiomi
Sakai, Miyu
Hamano, Yui
Yoshida, Maria
Yamakura, Fumiyuki
author_sort Hatsuda, Machiko
collection PubMed
description The impact of deep space cosmic rays on food resources is as important as the risks of cosmic rays to the human body. This study demonstrates the potential for neutrons as secondary radiation in deep space spacecraft to cause meat activation and oxidative modification of proteins and lipids. We conducted a series of experiments such as the neutron irradiation experiment, the radioactivation analysis and the biochemical analysis. Neutrons with energies from 1 to 5 MeV with doses from 0.01 Gy to 4 Gy were irradiated by the RIKEN accelerated-driven neutron source (RANS). Radioactive nuclei, (24)Na, (42)K, and (38)Cl, were detected in the neutron-irradiated meat. The modification products of the proteins by oxidative nitration, 6-nitrotryptophan (6NO(2)Trp), and by a lipid peroxidation, 4-hydroxy-2-nonenal (4-HNE), were detected in several proteins with neutron dose dependent. The proteome analysis showed that many oxidative modifications were detected in actin and myosin which are major proteins of myofibrils. This study is of crucial importance not only as risk factors for human space exploration, but also as fundamental effects of radiation on the components of the human body.
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spelling pubmed-103940552023-08-03 Effects of neutron radiation generated in deep space-like environments on food resources Hatsuda, Machiko Kawasaki, Hiroaki Shigenaga, Ayako Taketani, Atsushi Takanashi, Takaoki Wakabayashi, Yasuo Otake, Yoshie Kamata, Yayoi Ichinose, Akari Nishioka, Honoka Kimura, Hayato Koganei, Yumi Komoriya, Shiomi Sakai, Miyu Hamano, Yui Yoshida, Maria Yamakura, Fumiyuki Sci Rep Article The impact of deep space cosmic rays on food resources is as important as the risks of cosmic rays to the human body. This study demonstrates the potential for neutrons as secondary radiation in deep space spacecraft to cause meat activation and oxidative modification of proteins and lipids. We conducted a series of experiments such as the neutron irradiation experiment, the radioactivation analysis and the biochemical analysis. Neutrons with energies from 1 to 5 MeV with doses from 0.01 Gy to 4 Gy were irradiated by the RIKEN accelerated-driven neutron source (RANS). Radioactive nuclei, (24)Na, (42)K, and (38)Cl, were detected in the neutron-irradiated meat. The modification products of the proteins by oxidative nitration, 6-nitrotryptophan (6NO(2)Trp), and by a lipid peroxidation, 4-hydroxy-2-nonenal (4-HNE), were detected in several proteins with neutron dose dependent. The proteome analysis showed that many oxidative modifications were detected in actin and myosin which are major proteins of myofibrils. This study is of crucial importance not only as risk factors for human space exploration, but also as fundamental effects of radiation on the components of the human body. Nature Publishing Group UK 2023-08-01 /pmc/articles/PMC10394055/ /pubmed/37528144 http://dx.doi.org/10.1038/s41598-023-38990-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Hatsuda, Machiko
Kawasaki, Hiroaki
Shigenaga, Ayako
Taketani, Atsushi
Takanashi, Takaoki
Wakabayashi, Yasuo
Otake, Yoshie
Kamata, Yayoi
Ichinose, Akari
Nishioka, Honoka
Kimura, Hayato
Koganei, Yumi
Komoriya, Shiomi
Sakai, Miyu
Hamano, Yui
Yoshida, Maria
Yamakura, Fumiyuki
Effects of neutron radiation generated in deep space-like environments on food resources
title Effects of neutron radiation generated in deep space-like environments on food resources
title_full Effects of neutron radiation generated in deep space-like environments on food resources
title_fullStr Effects of neutron radiation generated in deep space-like environments on food resources
title_full_unstemmed Effects of neutron radiation generated in deep space-like environments on food resources
title_short Effects of neutron radiation generated in deep space-like environments on food resources
title_sort effects of neutron radiation generated in deep space-like environments on food resources
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394055/
https://www.ncbi.nlm.nih.gov/pubmed/37528144
http://dx.doi.org/10.1038/s41598-023-38990-1
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