VAPB-mediated ER-targeting stabilizes IRS-1 signalosomes to regulate insulin/IGF signaling

The scaffold protein IRS-1 is an essential node in insulin/IGF signaling. It has long been recognized that the stability of IRS-1 is dependent on its endomembrane targeting. However, how IRS-1 targets the intracellular membrane, and what type of intracellular membrane is actually targeted, remains p...

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Detalles Bibliográficos
Autores principales: Gao, Xiu Kui, Sheng, Zu Kang, Lu, Ye Hong, Sun, Yu Ting, Rao, Xi Sheng, Shi, Lin Jing, Cong, Xiao Xia, Chen, Xiao, Wu, Hao Bo, Huang, Man, Zheng, Qiang, Guo, Jian-sheng, Jiang, Liang Jun, Zheng, Li Ling, Zhou, Yi Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394085/
https://www.ncbi.nlm.nih.gov/pubmed/37528084
http://dx.doi.org/10.1038/s41421-023-00576-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394085/
https://www.ncbi.nlm.nih.gov/pubmed/37528084
http://dx.doi.org/10.1038/s41421-023-00576-6

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