Integrating genetics and metabolomics from multi-ethnic and multi-fluid data reveals putative mechanisms for age-related macular degeneration

Age-related macular degeneration (AMD) is a leading cause of blindness in older adults. Investigating shared genetic components between metabolites and AMD can enhance our understanding of its pathogenesis. We conduct metabolite genome-wide association studies (mGWASs) using multi-ethnic genetic and...

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Detalles Bibliográficos
Autores principales: Han, Xikun, Lains, Ines, Li, Jun, Li, Jinglun, Chen, Yiheng, Yu, Bing, Qi, Qibin, Boerwinkle, Eric, Kaplan, Robert, Thyagarajan, Bharat, Daviglus, Martha, Joslin, Charlotte E., Cai, Jianwen, Guasch-Ferré, Marta, Tobias, Deirdre K., Rimm, Eric, Ascherio, Alberto, Costenbader, Karen, Karlson, Elizabeth, Mucci, Lorelei, Eliassen, A. Heather, Zeleznik, Oana, Miller, John, Vavvas, Demetrios G., Kim, Ivana K., Silva, Rufino, Miller, Joan, Hu, Frank, Willett, Walter, Lasky-Su, Jessica, Kraft, Peter, Richards, J. Brent, MacGregor, Stuart, Husain, Deeba, Liang, Liming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394104/
https://www.ncbi.nlm.nih.gov/pubmed/37348500
http://dx.doi.org/10.1016/j.xcrm.2023.101085

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