Single-cell dissection of Merkel cell carcinoma heterogeneity unveils transcriptomic plasticity and therapeutic vulnerabilities

Merkel cell carcinoma (MCC), a rare but aggressive skin cancer, remains a challenge in the era of precision medicine. Immune checkpoint inhibitors (ICIs), the only approved therapy for advanced MCC, are impeded by high primary and acquired resistance. Hence, we dissect transcriptomic heterogeneity a...

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Detalles Bibliográficos
Autores principales: Das, Bhaba K., Kannan, Aarthi, Velasco, Graham J., Kunika, Mikaela D., Lambrecht, Nils, Nguyen, Quy, Zhao, Haibo, Wu, Jie, Gao, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394170/
https://www.ncbi.nlm.nih.gov/pubmed/37421947
http://dx.doi.org/10.1016/j.xcrm.2023.101101

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