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Tumor and local lymphoid tissue interaction determines prognosis in high-grade serous ovarian cancer

Tertiary lymphoid structure (TLS) is associated with prognosis in copy-number-driven tumors, including high-grade serous ovarian cancer (HGSOC), although the function of TLS and its interaction with copy-number alterations in HGSOC are not fully understood. In the current study, we confirm that TLS-...

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Autores principales: Lu, Haonan, Lou, Hantao, Wengert, Georg, Paudel, Reema, Patel, Naina, Desai, Saral, Crum, Bill, Linton-Reid, Kristofer, Chen, Mitchell, Li, Dongyang, Ip, Jacey, Mauri, Francesco, Pinato, David J., Rockall, Andrea, Copley, Susan J., Ghaem-Maghami, Sadaf, Aboagye, Eric O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394173/
https://www.ncbi.nlm.nih.gov/pubmed/37348499
http://dx.doi.org/10.1016/j.xcrm.2023.101092
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author Lu, Haonan
Lou, Hantao
Wengert, Georg
Paudel, Reema
Patel, Naina
Desai, Saral
Crum, Bill
Linton-Reid, Kristofer
Chen, Mitchell
Li, Dongyang
Ip, Jacey
Mauri, Francesco
Pinato, David J.
Rockall, Andrea
Copley, Susan J.
Ghaem-Maghami, Sadaf
Aboagye, Eric O.
author_facet Lu, Haonan
Lou, Hantao
Wengert, Georg
Paudel, Reema
Patel, Naina
Desai, Saral
Crum, Bill
Linton-Reid, Kristofer
Chen, Mitchell
Li, Dongyang
Ip, Jacey
Mauri, Francesco
Pinato, David J.
Rockall, Andrea
Copley, Susan J.
Ghaem-Maghami, Sadaf
Aboagye, Eric O.
author_sort Lu, Haonan
collection PubMed
description Tertiary lymphoid structure (TLS) is associated with prognosis in copy-number-driven tumors, including high-grade serous ovarian cancer (HGSOC), although the function of TLS and its interaction with copy-number alterations in HGSOC are not fully understood. In the current study, we confirm that TLS-high HGSOC patients show significantly better progression-free survival (PFS). We show that the presence of TLS in HGSOC tumors is associated with B cell maturation and cytotoxic tumor-specific T cell activation and proliferation. In addition, the copy-number loss of IL15 and CXCL10 may limit TLS formation in HGSOC; a list of genes that may dysregulate TLS function is also proposed. Last, a radiomics-based signature is developed to predict the presence of TLS, which independently predicts PFS in both HGSOC patients and immune checkpoint inhibitor (ICI)-treated non-small cell lung cancer (NSCLC) patients. Overall, we reveal that TLS coordinates intratumoral B cell and T cell response to HGSOC tumor, while the cancer genome evolves to counteract TLS formation and function.
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spelling pubmed-103941732023-08-03 Tumor and local lymphoid tissue interaction determines prognosis in high-grade serous ovarian cancer Lu, Haonan Lou, Hantao Wengert, Georg Paudel, Reema Patel, Naina Desai, Saral Crum, Bill Linton-Reid, Kristofer Chen, Mitchell Li, Dongyang Ip, Jacey Mauri, Francesco Pinato, David J. Rockall, Andrea Copley, Susan J. Ghaem-Maghami, Sadaf Aboagye, Eric O. Cell Rep Med Article Tertiary lymphoid structure (TLS) is associated with prognosis in copy-number-driven tumors, including high-grade serous ovarian cancer (HGSOC), although the function of TLS and its interaction with copy-number alterations in HGSOC are not fully understood. In the current study, we confirm that TLS-high HGSOC patients show significantly better progression-free survival (PFS). We show that the presence of TLS in HGSOC tumors is associated with B cell maturation and cytotoxic tumor-specific T cell activation and proliferation. In addition, the copy-number loss of IL15 and CXCL10 may limit TLS formation in HGSOC; a list of genes that may dysregulate TLS function is also proposed. Last, a radiomics-based signature is developed to predict the presence of TLS, which independently predicts PFS in both HGSOC patients and immune checkpoint inhibitor (ICI)-treated non-small cell lung cancer (NSCLC) patients. Overall, we reveal that TLS coordinates intratumoral B cell and T cell response to HGSOC tumor, while the cancer genome evolves to counteract TLS formation and function. Elsevier 2023-06-21 /pmc/articles/PMC10394173/ /pubmed/37348499 http://dx.doi.org/10.1016/j.xcrm.2023.101092 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lu, Haonan
Lou, Hantao
Wengert, Georg
Paudel, Reema
Patel, Naina
Desai, Saral
Crum, Bill
Linton-Reid, Kristofer
Chen, Mitchell
Li, Dongyang
Ip, Jacey
Mauri, Francesco
Pinato, David J.
Rockall, Andrea
Copley, Susan J.
Ghaem-Maghami, Sadaf
Aboagye, Eric O.
Tumor and local lymphoid tissue interaction determines prognosis in high-grade serous ovarian cancer
title Tumor and local lymphoid tissue interaction determines prognosis in high-grade serous ovarian cancer
title_full Tumor and local lymphoid tissue interaction determines prognosis in high-grade serous ovarian cancer
title_fullStr Tumor and local lymphoid tissue interaction determines prognosis in high-grade serous ovarian cancer
title_full_unstemmed Tumor and local lymphoid tissue interaction determines prognosis in high-grade serous ovarian cancer
title_short Tumor and local lymphoid tissue interaction determines prognosis in high-grade serous ovarian cancer
title_sort tumor and local lymphoid tissue interaction determines prognosis in high-grade serous ovarian cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394173/
https://www.ncbi.nlm.nih.gov/pubmed/37348499
http://dx.doi.org/10.1016/j.xcrm.2023.101092
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