Accelerated cystogenesis by dietary protein load is dependent on, but not initiated by kidney macrophages

BACKGROUND: Disease severity of autosomal dominant polycystic kidney disease (ADPKD) is influenced by diet. Dietary protein, a recognized cyst-accelerating factor, is catabolized into amino acids (AA) and delivered to the kidney leading to renal hypertrophy. Injury-induced hypertrophic signaling in...

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Detalles Bibliográficos
Autores principales: Sedaka, Randee, Huang, Jifeng, Yamaguchi, Shinobu, Lovelady, Caleb, Hsu, Jung-Shan, Shinde, Sejal, Kasztan, Malgorzata, Crossman, David K., Saigusa, Takamitsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394241/
https://www.ncbi.nlm.nih.gov/pubmed/37538309
http://dx.doi.org/10.3389/fmed.2023.1173674

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