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Specific inflammatory profile of acute ischemic stroke patients with left atrial enlargement

BACKGROUND: The inflammatory process underlying atrial myopathy may affect the inflammatory response activated in acute ischemic stroke (AIS). OBJECTIVES: We aimed to assess whether left atrial enlargement (LAE) as a marker of atrial myopathy is associated with a different profile of circulating inf...

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Autores principales: Fontaine, Julia, Leboube, Simon, Bochaton, Thomas, Thibault, Hélène, Amaz, Camille, Cho, Tae-Hee, Paccalet, Alexandre, Crola Da Silva, Claire, Duhamel, Suzanne, Buisson, Marielle, Rascle, Lucie, Bidaux, Gabriel, Ovize, Michel, Nighoghossian, Norbert, Mechtouff, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394294/
https://www.ncbi.nlm.nih.gov/pubmed/37539088
http://dx.doi.org/10.3389/fcvm.2023.1190857
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author Fontaine, Julia
Leboube, Simon
Bochaton, Thomas
Thibault, Hélène
Amaz, Camille
Cho, Tae-Hee
Paccalet, Alexandre
Crola Da Silva, Claire
Duhamel, Suzanne
Buisson, Marielle
Rascle, Lucie
Bidaux, Gabriel
Ovize, Michel
Nighoghossian, Norbert
Mechtouff, Laura
author_facet Fontaine, Julia
Leboube, Simon
Bochaton, Thomas
Thibault, Hélène
Amaz, Camille
Cho, Tae-Hee
Paccalet, Alexandre
Crola Da Silva, Claire
Duhamel, Suzanne
Buisson, Marielle
Rascle, Lucie
Bidaux, Gabriel
Ovize, Michel
Nighoghossian, Norbert
Mechtouff, Laura
author_sort Fontaine, Julia
collection PubMed
description BACKGROUND: The inflammatory process underlying atrial myopathy may affect the inflammatory response activated in acute ischemic stroke (AIS). OBJECTIVES: We aimed to assess whether left atrial enlargement (LAE) as a marker of atrial myopathy is associated with a different profile of circulating inflammatory markers in AIS patients. METHODS: HIBISCUS-STROKE is a cohort study including anterior circulation AIS patients treated with mechanical thrombectomy following MRI. Ten circulating inflammatory markers were measured at admission and 6, 24, and 48 h after admission. LAE was defined as a left atrial volume index (LAVi) ≥34 ml/m(2). A multiple logistic regression model was performed to detect an independent association between the area under the curve (AUC) of these markers and LAE. RESULTS: We included 143 patients. Of them, 85 (59.4%) had LAE. On univariable analysis, we found that patients with LAE had higher soluble form suppression of tumorigenicity 2 (sST2), soluble tumor necrosis factor receptor I (sTNFR1), and vascular cellular adhesion molecule-1 (VCAM-1) AUC, were older, mostly female, had a higher National Institutes of Health Stroke Scale (NIHSS) score and blood glucose level at admission, had more often hypertension, and a cardioembolic source of AIS, such as atrial fibrillation, while they were less frequently current smokers and had a lower rate of tandem occlusion than patients without LAE. On multivariable analysis, we found that among circulating inflammatory markers, only high VCAM-1 (OR: 9.13, 95% CI: 3.21–25.9) and sST2 (OR: 3.40, 95% CI: 1.68–6.86) AUC remained associated with LAE. CONCLUSIONS: High VCAM-1 and sST2 levels within the first 48 h are associated with LAE in AIS patients.
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spelling pubmed-103942942023-08-03 Specific inflammatory profile of acute ischemic stroke patients with left atrial enlargement Fontaine, Julia Leboube, Simon Bochaton, Thomas Thibault, Hélène Amaz, Camille Cho, Tae-Hee Paccalet, Alexandre Crola Da Silva, Claire Duhamel, Suzanne Buisson, Marielle Rascle, Lucie Bidaux, Gabriel Ovize, Michel Nighoghossian, Norbert Mechtouff, Laura Front Cardiovasc Med Cardiovascular Medicine BACKGROUND: The inflammatory process underlying atrial myopathy may affect the inflammatory response activated in acute ischemic stroke (AIS). OBJECTIVES: We aimed to assess whether left atrial enlargement (LAE) as a marker of atrial myopathy is associated with a different profile of circulating inflammatory markers in AIS patients. METHODS: HIBISCUS-STROKE is a cohort study including anterior circulation AIS patients treated with mechanical thrombectomy following MRI. Ten circulating inflammatory markers were measured at admission and 6, 24, and 48 h after admission. LAE was defined as a left atrial volume index (LAVi) ≥34 ml/m(2). A multiple logistic regression model was performed to detect an independent association between the area under the curve (AUC) of these markers and LAE. RESULTS: We included 143 patients. Of them, 85 (59.4%) had LAE. On univariable analysis, we found that patients with LAE had higher soluble form suppression of tumorigenicity 2 (sST2), soluble tumor necrosis factor receptor I (sTNFR1), and vascular cellular adhesion molecule-1 (VCAM-1) AUC, were older, mostly female, had a higher National Institutes of Health Stroke Scale (NIHSS) score and blood glucose level at admission, had more often hypertension, and a cardioembolic source of AIS, such as atrial fibrillation, while they were less frequently current smokers and had a lower rate of tandem occlusion than patients without LAE. On multivariable analysis, we found that among circulating inflammatory markers, only high VCAM-1 (OR: 9.13, 95% CI: 3.21–25.9) and sST2 (OR: 3.40, 95% CI: 1.68–6.86) AUC remained associated with LAE. CONCLUSIONS: High VCAM-1 and sST2 levels within the first 48 h are associated with LAE in AIS patients. Frontiers Media S.A. 2023-07-19 /pmc/articles/PMC10394294/ /pubmed/37539088 http://dx.doi.org/10.3389/fcvm.2023.1190857 Text en © 2023 Fontaine, Leboube, Bochaton, Thibault, Amaz, Cho, Paccalet, Crola Da Silva, Duhamel, Buisson, Rascle, Bidaux, Ovize, Nighoghossian and Mechtouff. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Fontaine, Julia
Leboube, Simon
Bochaton, Thomas
Thibault, Hélène
Amaz, Camille
Cho, Tae-Hee
Paccalet, Alexandre
Crola Da Silva, Claire
Duhamel, Suzanne
Buisson, Marielle
Rascle, Lucie
Bidaux, Gabriel
Ovize, Michel
Nighoghossian, Norbert
Mechtouff, Laura
Specific inflammatory profile of acute ischemic stroke patients with left atrial enlargement
title Specific inflammatory profile of acute ischemic stroke patients with left atrial enlargement
title_full Specific inflammatory profile of acute ischemic stroke patients with left atrial enlargement
title_fullStr Specific inflammatory profile of acute ischemic stroke patients with left atrial enlargement
title_full_unstemmed Specific inflammatory profile of acute ischemic stroke patients with left atrial enlargement
title_short Specific inflammatory profile of acute ischemic stroke patients with left atrial enlargement
title_sort specific inflammatory profile of acute ischemic stroke patients with left atrial enlargement
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394294/
https://www.ncbi.nlm.nih.gov/pubmed/37539088
http://dx.doi.org/10.3389/fcvm.2023.1190857
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