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High-Frequency Repetitive Magnetic Stimulation at the Sacrum Alleviates Chronic Constipation in Parkinson’s Patients

OBJECTIVE: This study was to investigate the therapeutic effect of high-frequency repetitive magnetic stimulation (HF-rMS) at the sacrum for chronic constipation in Parkinson’s patients (PD). MATERIALS AND METHODS: Eventually 48 PD patients were enrolled from July 2019 to October 2020, and randomly...

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Autores principales: Huang, Mei, Zheng, Bofang, Zhou, Wanfei, Fu, Huaili, Chen, Xinrun, Wu, Heyong, Zhang, Jianguo, Zhou, Xianju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394460/
https://www.ncbi.nlm.nih.gov/pubmed/37538410
http://dx.doi.org/10.4103/aian.aian_1001_22
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author Huang, Mei
Zheng, Bofang
Zhou, Wanfei
Fu, Huaili
Chen, Xinrun
Wu, Heyong
Zhang, Jianguo
Zhou, Xianju
author_facet Huang, Mei
Zheng, Bofang
Zhou, Wanfei
Fu, Huaili
Chen, Xinrun
Wu, Heyong
Zhang, Jianguo
Zhou, Xianju
author_sort Huang, Mei
collection PubMed
description OBJECTIVE: This study was to investigate the therapeutic effect of high-frequency repetitive magnetic stimulation (HF-rMS) at the sacrum for chronic constipation in Parkinson’s patients (PD). MATERIALS AND METHODS: Eventually 48 PD patients were enrolled from July 2019 to October 2020, and randomly divided into the HF-rMS group (the intervention group, n = 24) and the sham HF-rMS group (the control group, n = 24). The intervention group received HF-rMS at the sacrum, whereas the control group received ineffective magnetic stimulation. We performed clinical evaluation before and after HF-rMS treatment, including constipation score scale (KESS questionnaire), Unified Parkinson’s Disease Rating Scale (UPDRS-III exercise examination), Hoehn-Yahr (H-Y) stage of motor function; simple mental status scale (MMSE), anxiety/depression table (HAD-A/HAD-D), the activity of daily living (ADL), and quality of life scale for patients with constipation (PAC-QOL) to evaluate symptoms and satisfaction of PD patients with chronic constipation. RESULTS: There was no significant difference in the clinical characteristics between the two groups. As compared to the control group, the HF-rMS group displayed a larger change (pre and posttreatment) in the KESS scores of PD patients with chronic constipation, suggesting a significant improvement. Moreover, HF-rMS significantly promoted the mood, activity of daily living, and quality of life of PD patients when comparing the alteration of HAD-A/HAD-D scores, ADL scores, and PAC-QOL scores between the two groups. Finally, there was no significant difference in the change of the UPDRS III score and the MMSE score between the two groups. CONCLUSION: HF-rMS at the sacrum can improve chronic constipation in PD patients.
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spelling pubmed-103944602023-08-03 High-Frequency Repetitive Magnetic Stimulation at the Sacrum Alleviates Chronic Constipation in Parkinson’s Patients Huang, Mei Zheng, Bofang Zhou, Wanfei Fu, Huaili Chen, Xinrun Wu, Heyong Zhang, Jianguo Zhou, Xianju Ann Indian Acad Neurol Original Article OBJECTIVE: This study was to investigate the therapeutic effect of high-frequency repetitive magnetic stimulation (HF-rMS) at the sacrum for chronic constipation in Parkinson’s patients (PD). MATERIALS AND METHODS: Eventually 48 PD patients were enrolled from July 2019 to October 2020, and randomly divided into the HF-rMS group (the intervention group, n = 24) and the sham HF-rMS group (the control group, n = 24). The intervention group received HF-rMS at the sacrum, whereas the control group received ineffective magnetic stimulation. We performed clinical evaluation before and after HF-rMS treatment, including constipation score scale (KESS questionnaire), Unified Parkinson’s Disease Rating Scale (UPDRS-III exercise examination), Hoehn-Yahr (H-Y) stage of motor function; simple mental status scale (MMSE), anxiety/depression table (HAD-A/HAD-D), the activity of daily living (ADL), and quality of life scale for patients with constipation (PAC-QOL) to evaluate symptoms and satisfaction of PD patients with chronic constipation. RESULTS: There was no significant difference in the clinical characteristics between the two groups. As compared to the control group, the HF-rMS group displayed a larger change (pre and posttreatment) in the KESS scores of PD patients with chronic constipation, suggesting a significant improvement. Moreover, HF-rMS significantly promoted the mood, activity of daily living, and quality of life of PD patients when comparing the alteration of HAD-A/HAD-D scores, ADL scores, and PAC-QOL scores between the two groups. Finally, there was no significant difference in the change of the UPDRS III score and the MMSE score between the two groups. CONCLUSION: HF-rMS at the sacrum can improve chronic constipation in PD patients. Wolters Kluwer - Medknow 2023 2023-04-07 /pmc/articles/PMC10394460/ /pubmed/37538410 http://dx.doi.org/10.4103/aian.aian_1001_22 Text en Copyright: © 2023 Annals of Indian Academy of Neurology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Huang, Mei
Zheng, Bofang
Zhou, Wanfei
Fu, Huaili
Chen, Xinrun
Wu, Heyong
Zhang, Jianguo
Zhou, Xianju
High-Frequency Repetitive Magnetic Stimulation at the Sacrum Alleviates Chronic Constipation in Parkinson’s Patients
title High-Frequency Repetitive Magnetic Stimulation at the Sacrum Alleviates Chronic Constipation in Parkinson’s Patients
title_full High-Frequency Repetitive Magnetic Stimulation at the Sacrum Alleviates Chronic Constipation in Parkinson’s Patients
title_fullStr High-Frequency Repetitive Magnetic Stimulation at the Sacrum Alleviates Chronic Constipation in Parkinson’s Patients
title_full_unstemmed High-Frequency Repetitive Magnetic Stimulation at the Sacrum Alleviates Chronic Constipation in Parkinson’s Patients
title_short High-Frequency Repetitive Magnetic Stimulation at the Sacrum Alleviates Chronic Constipation in Parkinson’s Patients
title_sort high-frequency repetitive magnetic stimulation at the sacrum alleviates chronic constipation in parkinson’s patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394460/
https://www.ncbi.nlm.nih.gov/pubmed/37538410
http://dx.doi.org/10.4103/aian.aian_1001_22
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