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Safety and efficacy of a feed additive consisting of endo‐β‐1,4‐xylanase produced by Komagataella phaffii CGMCC 7.371 (VTR‐xylanase) for all avian species, piglets (suckling and weaned) and minor growing porcine species (Victory Enzymes GmbH)

Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of endo‐β‐1,4‐xylanase (VTR‐xylanase) as a zootechnical feed additive for all avian species, pigl...

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Autores principales: Bampidis, Vasileios, Azimonti, Giovanna, Bastos, Maria de Lourdes, Christensen, Henrik, Dusemund, Birgit, Durjava, Mojca, Kouba, Maryline, López‐Alonso, Marta, López Puente, Secundino, Marcon, Francesca, Mayo, Baltasar, Pechová, Alena, Petkova, Mariana, Ramos, Fernando, Sanz, Yolanda, Villa, Roberto Edoardo, Woutersen, Ruud, Brantom, Paul, Martelli, Giovanna, Svensson, Kettil, Anguita, Montserrat, Brozzi, Rosella, Galobart, Jaume, Innocenti, Matteo, Pettenati, Elisa, Pizzo, Fabiola, Tarrés‐Call, Jordi, Ortuño, Jordi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394589/
https://www.ncbi.nlm.nih.gov/pubmed/37539080
http://dx.doi.org/10.2903/j.efsa.2023.8150
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author Bampidis, Vasileios
Azimonti, Giovanna
Bastos, Maria de Lourdes
Christensen, Henrik
Dusemund, Birgit
Durjava, Mojca
Kouba, Maryline
López‐Alonso, Marta
López Puente, Secundino
Marcon, Francesca
Mayo, Baltasar
Pechová, Alena
Petkova, Mariana
Ramos, Fernando
Sanz, Yolanda
Villa, Roberto Edoardo
Woutersen, Ruud
Brantom, Paul
Martelli, Giovanna
Svensson, Kettil
Anguita, Montserrat
Brozzi, Rosella
Galobart, Jaume
Innocenti, Matteo
Pettenati, Elisa
Pizzo, Fabiola
Tarrés‐Call, Jordi
Ortuño, Jordi
author_facet Bampidis, Vasileios
Azimonti, Giovanna
Bastos, Maria de Lourdes
Christensen, Henrik
Dusemund, Birgit
Durjava, Mojca
Kouba, Maryline
López‐Alonso, Marta
López Puente, Secundino
Marcon, Francesca
Mayo, Baltasar
Pechová, Alena
Petkova, Mariana
Ramos, Fernando
Sanz, Yolanda
Villa, Roberto Edoardo
Woutersen, Ruud
Brantom, Paul
Martelli, Giovanna
Svensson, Kettil
Anguita, Montserrat
Brozzi, Rosella
Galobart, Jaume
Innocenti, Matteo
Pettenati, Elisa
Pizzo, Fabiola
Tarrés‐Call, Jordi
Ortuño, Jordi
collection PubMed
description Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of endo‐β‐1,4‐xylanase (VTR‐xylanase) as a zootechnical feed additive for all avian species, piglets (suckling and weaned) and minor growing porcine species. VTR‐xylanase is available in a powder and a liquid form and is produced by a genetically modified strain of Komagataella phaffii (CGMCC 7.371). The genetic modification of the production strain does not give rise to safety concerns. Viable cells of the production strain and its DNA were not detected in the final products. The additive does not pose any safety concern regarding the production strain. VTR xylanase (powder/liquid) produced by Komagataella phaffii CGMCC 7.371 is safe for all avian species, piglets and minor growing porcine species at the proposed conditions of use. The use of both forms of the additive under assessment in animal nutrition under the proposed conditions of use raises no safety concerns for consumers or for the environment. The liquid and powder formulations of VTR‐xylanase are non‐irritant to eyes but should be considered skin sensitisers. No conclusions can be drawn on the potential of the final formulations of the additive to be irritant to skin. Due to the proteinaceous nature of the active substance, the additive is a respiratory sensitiser. The additive has the potential to be efficacious in all laying birds and piglets (suckling and weaned) from all Suidae at 2,000 U/kg and in all other avian species/categories at 1,000 U/kg feed.
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spelling pubmed-103945892023-08-03 Safety and efficacy of a feed additive consisting of endo‐β‐1,4‐xylanase produced by Komagataella phaffii CGMCC 7.371 (VTR‐xylanase) for all avian species, piglets (suckling and weaned) and minor growing porcine species (Victory Enzymes GmbH) Bampidis, Vasileios Azimonti, Giovanna Bastos, Maria de Lourdes Christensen, Henrik Dusemund, Birgit Durjava, Mojca Kouba, Maryline López‐Alonso, Marta López Puente, Secundino Marcon, Francesca Mayo, Baltasar Pechová, Alena Petkova, Mariana Ramos, Fernando Sanz, Yolanda Villa, Roberto Edoardo Woutersen, Ruud Brantom, Paul Martelli, Giovanna Svensson, Kettil Anguita, Montserrat Brozzi, Rosella Galobart, Jaume Innocenti, Matteo Pettenati, Elisa Pizzo, Fabiola Tarrés‐Call, Jordi Ortuño, Jordi EFSA J Scientific Opinion Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of endo‐β‐1,4‐xylanase (VTR‐xylanase) as a zootechnical feed additive for all avian species, piglets (suckling and weaned) and minor growing porcine species. VTR‐xylanase is available in a powder and a liquid form and is produced by a genetically modified strain of Komagataella phaffii (CGMCC 7.371). The genetic modification of the production strain does not give rise to safety concerns. Viable cells of the production strain and its DNA were not detected in the final products. The additive does not pose any safety concern regarding the production strain. VTR xylanase (powder/liquid) produced by Komagataella phaffii CGMCC 7.371 is safe for all avian species, piglets and minor growing porcine species at the proposed conditions of use. The use of both forms of the additive under assessment in animal nutrition under the proposed conditions of use raises no safety concerns for consumers or for the environment. The liquid and powder formulations of VTR‐xylanase are non‐irritant to eyes but should be considered skin sensitisers. No conclusions can be drawn on the potential of the final formulations of the additive to be irritant to skin. Due to the proteinaceous nature of the active substance, the additive is a respiratory sensitiser. The additive has the potential to be efficacious in all laying birds and piglets (suckling and weaned) from all Suidae at 2,000 U/kg and in all other avian species/categories at 1,000 U/kg feed. John Wiley and Sons Inc. 2023-08-02 /pmc/articles/PMC10394589/ /pubmed/37539080 http://dx.doi.org/10.2903/j.efsa.2023.8150 Text en © 2023 European Food Safety Authority. EFSA Journal published by Wiley‐VCH GmbH on behalf of European Food Safety Authority. https://creativecommons.org/licenses/by-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ (https://creativecommons.org/licenses/by-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.
spellingShingle Scientific Opinion
Bampidis, Vasileios
Azimonti, Giovanna
Bastos, Maria de Lourdes
Christensen, Henrik
Dusemund, Birgit
Durjava, Mojca
Kouba, Maryline
López‐Alonso, Marta
López Puente, Secundino
Marcon, Francesca
Mayo, Baltasar
Pechová, Alena
Petkova, Mariana
Ramos, Fernando
Sanz, Yolanda
Villa, Roberto Edoardo
Woutersen, Ruud
Brantom, Paul
Martelli, Giovanna
Svensson, Kettil
Anguita, Montserrat
Brozzi, Rosella
Galobart, Jaume
Innocenti, Matteo
Pettenati, Elisa
Pizzo, Fabiola
Tarrés‐Call, Jordi
Ortuño, Jordi
Safety and efficacy of a feed additive consisting of endo‐β‐1,4‐xylanase produced by Komagataella phaffii CGMCC 7.371 (VTR‐xylanase) for all avian species, piglets (suckling and weaned) and minor growing porcine species (Victory Enzymes GmbH)
title Safety and efficacy of a feed additive consisting of endo‐β‐1,4‐xylanase produced by Komagataella phaffii CGMCC 7.371 (VTR‐xylanase) for all avian species, piglets (suckling and weaned) and minor growing porcine species (Victory Enzymes GmbH)
title_full Safety and efficacy of a feed additive consisting of endo‐β‐1,4‐xylanase produced by Komagataella phaffii CGMCC 7.371 (VTR‐xylanase) for all avian species, piglets (suckling and weaned) and minor growing porcine species (Victory Enzymes GmbH)
title_fullStr Safety and efficacy of a feed additive consisting of endo‐β‐1,4‐xylanase produced by Komagataella phaffii CGMCC 7.371 (VTR‐xylanase) for all avian species, piglets (suckling and weaned) and minor growing porcine species (Victory Enzymes GmbH)
title_full_unstemmed Safety and efficacy of a feed additive consisting of endo‐β‐1,4‐xylanase produced by Komagataella phaffii CGMCC 7.371 (VTR‐xylanase) for all avian species, piglets (suckling and weaned) and minor growing porcine species (Victory Enzymes GmbH)
title_short Safety and efficacy of a feed additive consisting of endo‐β‐1,4‐xylanase produced by Komagataella phaffii CGMCC 7.371 (VTR‐xylanase) for all avian species, piglets (suckling and weaned) and minor growing porcine species (Victory Enzymes GmbH)
title_sort safety and efficacy of a feed additive consisting of endo‐β‐1,4‐xylanase produced by komagataella phaffii cgmcc 7.371 (vtr‐xylanase) for all avian species, piglets (suckling and weaned) and minor growing porcine species (victory enzymes gmbh)
topic Scientific Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394589/
https://www.ncbi.nlm.nih.gov/pubmed/37539080
http://dx.doi.org/10.2903/j.efsa.2023.8150
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