Cargando…

Mechanism of action of icaritin on uterine corpus endometrial carcinoma based on network pharmacology and experimental evaluation

BACKGROUND: Uterine corpus endometrial carcinoma (UCEC) belongs to a group of epithelial malignant tumors. Icaritin is the main active compound of Epimedii Folium. Icaritin has been utilized to induce UCEC cells to death. METHODS: We wished to identify potential targets for icaritin in the treatment...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jin, Yan-Bin, Liang, Xiao-Chen, Cai, Jun-Hong, Wang, Kang, Wang, Chen-Yang, Wang, Wen-Hua, Chen, Xiu-Li, Bao, Shan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394632/ https://www.ncbi.nlm.nih.gov/pubmed/37538114 http://dx.doi.org/10.3389/fonc.2023.1205604

Ejemplares similares

Identification of Hub Genes Correlated With Poor Prognosis for Patients With Uterine Corpus Endometrial Carcinoma by Integrated Bioinformatics Analysis and Experimental Validation
por: Yuan, Yi, et al.
Publicado: (2021)

Integrated bioinformatics analysis and experimental validation reveals fatty acid metabolism-related prognostic signature and immune responses for uterine corpus endometrial carcinoma
por: Guo, Chenrui, et al.
Publicado: (2022)

KNL1 is a prognostic and diagnostic biomarker related to immune infiltration in patients with uterine corpus endometrial carcinoma
por: He, Kang, et al.
Publicado: (2023)

Inflammation-Related LncRNAs Signature for Prognosis and Immune Response Evaluation in Uterine Corpus Endometrial Carcinoma
por: Gu, Hongmei, et al.
Publicado: (2022)

A prognostic model and immune regulation analysis of uterine corpus endometrial carcinoma based on cellular senescence
por: Gao, Lulu, et al.
Publicado: (2022)

Investigating the effect of Icaritin on hepatocellular carcinoma based on network pharmacology
por: Xue, Zhong, et al.
Publicado: (2023)

Identification of an integrated kinase-related prognostic gene signature associated with tumor immune microenvironment in human uterine corpus endometrial carcinoma
por: Wei, Sitian, et al.
Publicado: (2022)

Pan-cancer analysis identifies LIFR as a prognostic and immunological biomarker for uterine corpus endometrial carcinoma
por: Zhang, Fang, et al.
Publicado: (2023)

RPP40 is a prognostic biomarker and correlated with tumor microenvironment in uterine corpus endometrial carcinoma
por: Tang, Jianming, et al.
Publicado: (2022)

Icaritin inhibits decidualization of endometrial stromal cells
por: Le, Aiwen, et al.
Publicado: (2017)

The IFN-γ-related long non-coding RNA signature predicts prognosis and indicates immune microenvironment infiltration in uterine corpus endometrial carcinoma
por: Gu, Chunyan, et al.
Publicado: (2022)

Endoplasmic reticulum stress related IncRNA signature predicts the prognosis and immune response evaluation of uterine corpus endometrial carcinoma
por: Chen, Jun, et al.
Publicado: (2023)

The Expression of Pyroptosis-Related Gene May Influence the Occurrence, Development, and Prognosis of Uterine Corpus Endometrial Carcinoma
por: Huang, Xiaoling, et al.
Publicado: (2022)

CXCL9 correlates with antitumor immunity and is predictive of a favorable prognosis in uterine corpus endometrial carcinoma
por: Xue, Shen, et al.
Publicado: (2023)

Exploring the pharmacological mechanisms of icaritin against nasopharyngeal carcinoma via network pharmacology and experimental validation
por: Liu, Minglu, et al.
Publicado: (2022)

Immune Infiltrates of m5C RNA Methylation-Related LncRNAs in Uterine Corpus Endometrial Carcinoma
por: Gu, Wen-Xiu, et al.
Publicado: (2022)

Corrigendum: Exploring the pharmacological mechanisms of icaritin against nasopharyngeal carcinoma via network pharmacology and experimental validation
por: Liu, Minglu, et al.
Publicado: (2023)

MCM10: An effective treatment target and a prognostic biomarker in patients with uterine corpus endometrial carcinoma
por: Chen, Junyu, et al.
Publicado: (2023)

Comprehensive bioinformatic analyses of lncRNA-mediated ceRNA network for uterine corpus endometrial carcinoma
por: Cai, Yiran, et al.
Publicado: (2022)

Mechanism investigation and experiment validation of capsaicin on uterine corpus endometrial carcinoma
por: Lin, Zhiheng, et al.
Publicado: (2022)

A comparative study on the in vitro and in vivo antitumor efficacy of icaritin and hydrous icaritin nanorods
por: Li, Haowen, et al.
Publicado: (2020)

Icaritin ameliorates RANKL-mediated osteoclastogenesis and ovariectomy-induced osteoporosis
por: Huang, Jun-ming, et al.
Publicado: (2023)

The landscape and prognostic value of immune characteristics in uterine corpus endometrial cancer
por: Liu, Wenli, et al.
Publicado: (2021)

A Novel Set of WNT Pathway Effectors as a Predictive Marker of Uterine Corpus Endometrial Carcinoma–Study Based on Weighted Co-expression Matrices
por: Kośla, Katarzyna, et al.
Publicado: (2019)

Icaritin Causes Sustained ERK1/2 Activation and Induces Apoptosis in Human Endometrial Cancer Cells
por: Tong, Jing-Shan, et al.
Publicado: (2011)

Metabolism-associated molecular classification of uterine corpus endometrial carcinoma
por: Zhao, Munan, et al.
Publicado: (2023)

Icaritin Inhibits Migration and Invasion of Human Ovarian Cancer Cells via the Akt/mTOR Signaling Pathway
por: Gao, Lvfen, et al.
Publicado: (2022)

Construction of a Competitive Endogenous RNA Network in Uterine Corpus Endometrial Carcinoma
por: Ouyang, Dong, et al.
Publicado: (2019)

Prognostic significance of mutant-allele tumor heterogeneity in uterine corpus endometrial carcinoma
por: Hou, Yufang, et al.
Publicado: (2020)

Development of an Oxidative Phosphorylation-Related and Immune Microenvironment Prognostic Signature in Uterine Corpus Endometrial Carcinoma
por: Liu, Jinhui, et al.
Publicado: (2021)

Myelin and Lymphocyte Protein (MAL): A Novel Biomarker for Uterine Corpus Endometrial Carcinoma
por: Li, Dong, et al.
Publicado: (2021)

Downregulation of PSAT1 inhibits cell proliferation and migration in uterine corpus endometrial carcinoma
por: Wang, Min, et al.
Publicado: (2023)

Medical Significance of Uterine Corpus Endometrial Carcinoma Patients Infected With SARS-CoV-2 and Pharmacological Characteristics of Plumbagin
por: Li, Yongming, et al.
Publicado: (2021)

Erratum: Construction of a Competitive Endogenous RNA Network in Uterine Corpus Endometrial Carcinoma
por: Ouyang, Dong, et al.
Publicado: (2021)

Exploring Prognosis-Associated Biomarkers of Estrogen-Independent Uterine Corpus Endometrial Carcinoma by Bioinformatics Analysis
por: Ye, Youchun, et al.
Publicado: (2021)

Identification of lncRNAs associated with uterine corpus endometrial cancer prognosis based on the competing endogenous RNA network
por: Wang, Liangxiao, et al.
Publicado: (2023)

Identification and Validation of Cuproptosis-Related Prognostic Signature and Associated Regulatory Axis in Uterine Corpus Endometrial Carcinoma
por: Chen, Yun
Publicado: (2022)

PPP1R14B is a diagnostic prognostic marker in patients with uterine corpus endometrial carcinoma
por: He, Kang, et al.
Publicado: (2023)

FAT2 mutation is associated with better prognosis and responsiveness to immunotherapy in uterine corpus endometrial carcinoma
por: Wang, Zhe, et al.
Publicado: (2022)

The potential role of methyltransferase-like 5 in deficient mismatch repair of uterine corpus endometrial carcinoma
por: Liu, Xiaojuan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_dbla947e5f1g9vmsvqvv26jn5a