Inverse relationship between Fusobacterium nucleatum amount and tumor CD274 (PD‐L1) expression in colorectal carcinoma

OBJECTIVES: The CD274 (programmed cell death 1 ligand 1, PD‐L1)/PDCD1 (programmed cell death 1, PD‐1) immune checkpoint axis is known to regulate the antitumor immune response. Evidence also supports an immunosuppressive effect of Fusobacterium nucleatum. We hypothesised that tumor CD274 overexpress...

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Detalles Bibliográficos
Autores principales: Ugai, Tomotaka, Shimizu, Takashi, Kawamura, Hidetaka, Ugai, Satoko, Takashima, Yasutoshi, Usui, Genki, Väyrynen, Juha P, Okadome, Kazuo, Haruki, Koichiro, Akimoto, Naohiko, Masugi, Yohei, da Silva, Annacarolina, Mima, Kosuke, Zhang, Xuehong, Chan, Andrew T, Wang, Molin, Garrett, Wendy S, Freeman, Gordon J, Meyerhardt, Jeffrey A, Nowak, Jonathan A, Song, Mingyang, Giannakis, Marios, Ogino, Shuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394676/
https://www.ncbi.nlm.nih.gov/pubmed/37538192
http://dx.doi.org/10.1002/cti2.1453

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