Associations of obesity and body shape with erythrocyte and reticulocyte parameters in the UK Biobank cohort

BACKGROUND: Obesity is associated with type 2 diabetes mellitus and chronic low-grade inflammation. Although chronic inflammatory conditions and diabetes are associated with anaemia, less is known about associations of obesity and body shape, independent of each other, with erythrocyte and reticuloc...

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Autores principales: Christakoudi, Sofia, Tsilidis, Konstantinos K., Evangelou, Evangelos, Riboli, Elio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394790/
https://www.ncbi.nlm.nih.gov/pubmed/37528422
http://dx.doi.org/10.1186/s12902-023-01423-1
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author Christakoudi, Sofia
Tsilidis, Konstantinos K.
Evangelou, Evangelos
Riboli, Elio
author_facet Christakoudi, Sofia
Tsilidis, Konstantinos K.
Evangelou, Evangelos
Riboli, Elio
author_sort Christakoudi, Sofia
collection PubMed
description BACKGROUND: Obesity is associated with type 2 diabetes mellitus and chronic low-grade inflammation. Although chronic inflammatory conditions and diabetes are associated with anaemia, less is known about associations of obesity and body shape, independent of each other, with erythrocyte and reticulocyte parameters. METHODS: We investigated the associations of body mass index (BMI) and the allometric body shape index (ABSI) and hip index (HI), which are uncorrelated with BMI, with erythrocyte and reticulocyte parameters (all continuous, on a standard deviation (SD) scale) in UK Biobank participants without known metabolic, endocrine, or major inflammatory conditions (glycated haemoglobin HbA1c < 48 mmol/mol, C-reactive protein CRP < 10 mg/L). We examined erythrocyte count, total reticulocyte count and percent, immature reticulocyte count and fraction (IRF), haemoglobin, haematocrit, mean corpuscular haemoglobin mass (MCH) and concentration (MCHC), mean corpuscular and reticulocyte volumes (MCV, MRV), and red cell distribution width (RDW) in multivariable linear regression models. We additionally defined body shape phenotypes with dichotomised ABSI (≥ 73 women; ≥ 80 men) and HI (≥ 64 women; ≥ 49 men), including “pear” (small-ABSI-large-HI) and “apple” (large-ABSI-small-HI), and examined these in groups according to BMI (18.5–25 normal weight; 25–30 overweight; 30–45 kg/m(2) obese). RESULTS: In 105,853 women and 100,854 men, BMI and ABSI were associated positively with haemoglobin, haematocrit, and erythrocyte count, and more strongly with total reticulocyte count and percent, immature reticulocyte count and IRF. HI was associated inversely with all, but least with IRF. Associations were comparable in women and men. In groups according to obesity and body shape, erythrocyte count was ~ 0.6 SD higher for obese-“apple” compared to normal-weight-“pear” phenotype (SD = 0.31*10(12)/L women, SD = 0.34*10(12)/L men), total reticulocyte count was ~ 1.1 SD higher (SD = 21.1*10(9)/L women, SD = 23.6*10(9)/L men), immature reticulocyte count was ~ 1.2 SD higher (SD = 7.9*10(9)/L women, SD = 8.8*10(9)/L men), total reticulocyte percent was ~ 1.0 SD higher (SD = 0.48% women and men), and IFR was over 0.7 SD higher (SD = 5.7% women and men). BMI but not ABSI or HI was associated more weakly inversely with MCV, MRV, and MCH, but positively with MCHC in men and RDW in women. CONCLUSIONS: In obesity uncomplicated with diabetes, larger BMI and ABSI are associated with increased erythropoiesis and reticulocyte immaturity. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12902-023-01423-1.
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spelling pubmed-103947902023-08-03 Associations of obesity and body shape with erythrocyte and reticulocyte parameters in the UK Biobank cohort Christakoudi, Sofia Tsilidis, Konstantinos K. Evangelou, Evangelos Riboli, Elio BMC Endocr Disord Research BACKGROUND: Obesity is associated with type 2 diabetes mellitus and chronic low-grade inflammation. Although chronic inflammatory conditions and diabetes are associated with anaemia, less is known about associations of obesity and body shape, independent of each other, with erythrocyte and reticulocyte parameters. METHODS: We investigated the associations of body mass index (BMI) and the allometric body shape index (ABSI) and hip index (HI), which are uncorrelated with BMI, with erythrocyte and reticulocyte parameters (all continuous, on a standard deviation (SD) scale) in UK Biobank participants without known metabolic, endocrine, or major inflammatory conditions (glycated haemoglobin HbA1c < 48 mmol/mol, C-reactive protein CRP < 10 mg/L). We examined erythrocyte count, total reticulocyte count and percent, immature reticulocyte count and fraction (IRF), haemoglobin, haematocrit, mean corpuscular haemoglobin mass (MCH) and concentration (MCHC), mean corpuscular and reticulocyte volumes (MCV, MRV), and red cell distribution width (RDW) in multivariable linear regression models. We additionally defined body shape phenotypes with dichotomised ABSI (≥ 73 women; ≥ 80 men) and HI (≥ 64 women; ≥ 49 men), including “pear” (small-ABSI-large-HI) and “apple” (large-ABSI-small-HI), and examined these in groups according to BMI (18.5–25 normal weight; 25–30 overweight; 30–45 kg/m(2) obese). RESULTS: In 105,853 women and 100,854 men, BMI and ABSI were associated positively with haemoglobin, haematocrit, and erythrocyte count, and more strongly with total reticulocyte count and percent, immature reticulocyte count and IRF. HI was associated inversely with all, but least with IRF. Associations were comparable in women and men. In groups according to obesity and body shape, erythrocyte count was ~ 0.6 SD higher for obese-“apple” compared to normal-weight-“pear” phenotype (SD = 0.31*10(12)/L women, SD = 0.34*10(12)/L men), total reticulocyte count was ~ 1.1 SD higher (SD = 21.1*10(9)/L women, SD = 23.6*10(9)/L men), immature reticulocyte count was ~ 1.2 SD higher (SD = 7.9*10(9)/L women, SD = 8.8*10(9)/L men), total reticulocyte percent was ~ 1.0 SD higher (SD = 0.48% women and men), and IFR was over 0.7 SD higher (SD = 5.7% women and men). BMI but not ABSI or HI was associated more weakly inversely with MCV, MRV, and MCH, but positively with MCHC in men and RDW in women. CONCLUSIONS: In obesity uncomplicated with diabetes, larger BMI and ABSI are associated with increased erythropoiesis and reticulocyte immaturity. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12902-023-01423-1. BioMed Central 2023-08-02 /pmc/articles/PMC10394790/ /pubmed/37528422 http://dx.doi.org/10.1186/s12902-023-01423-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Christakoudi, Sofia
Tsilidis, Konstantinos K.
Evangelou, Evangelos
Riboli, Elio
Associations of obesity and body shape with erythrocyte and reticulocyte parameters in the UK Biobank cohort
title Associations of obesity and body shape with erythrocyte and reticulocyte parameters in the UK Biobank cohort
title_full Associations of obesity and body shape with erythrocyte and reticulocyte parameters in the UK Biobank cohort
title_fullStr Associations of obesity and body shape with erythrocyte and reticulocyte parameters in the UK Biobank cohort
title_full_unstemmed Associations of obesity and body shape with erythrocyte and reticulocyte parameters in the UK Biobank cohort
title_short Associations of obesity and body shape with erythrocyte and reticulocyte parameters in the UK Biobank cohort
title_sort associations of obesity and body shape with erythrocyte and reticulocyte parameters in the uk biobank cohort
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394790/
https://www.ncbi.nlm.nih.gov/pubmed/37528422
http://dx.doi.org/10.1186/s12902-023-01423-1
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