DNA hypermethylation driven by DNMT1 and DNMT3A favors tumor immune escape contributing to the aggressiveness of adrenocortical carcinoma

BACKGROUND: Adrenocortical carcinoma is rare and aggressive endocrine cancer of the adrenal gland. Within adrenocortical carcinoma, a recently described subtype characterized by a CpG island methylator phenotype (CIMP) has been associated with an especially poor prognosis. However, the drivers of CI...

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Detalles Bibliográficos
Autores principales: Kerdivel, Gwenneg, Amrouche, Floriane, Calmejane, Marie-Ange, Carallis, Floriane, Hamroune, Juliette, Hantel, Constanze, Bertherat, Jérôme, Assié, Guillaume, Boeva, Valentina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394822/
https://www.ncbi.nlm.nih.gov/pubmed/37528470
http://dx.doi.org/10.1186/s13148-023-01534-5

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