Phage resistance formation and fitness costs of hypervirulent Klebsiella pneumoniae mediated by K2 capsule-specific phage and the corresponding mechanisms

INTRODUCTION: Phage is promising for the treatment of hypervirulent Klebsiella pneumoniae (hvKP) infections. Although phage resistance seems inevitable, we found that there still was optimization space in phage therapy for hvKP infection. METHODS: The clinical isolate K. pneumoniae FK1979 was used t...

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Detalles Bibliográficos
Autores principales: Tang, Miran, Huang, Zeyu, Zhang, Xiaodong, Kong, Jingchun, Zhou, Beibei, Han, Yijia, Zhang, Yi, Chen, Lijiang, Zhou, Tieli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394836/
https://www.ncbi.nlm.nih.gov/pubmed/37538841
http://dx.doi.org/10.3389/fmicb.2023.1156292

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