Shank3 deletion in PV neurons is associated with abnormal behaviors and neuronal functions that are rescued by increasing GABAergic signaling

BACKGROUND: Phelan–McDermid syndrome (PMS) is a neurodevelopmental disorder characterized by developmental delay, intellectual disability, and autistic-like behaviors and is primarily caused by haploinsufficiency of SHANK3 gene. Currently, there is no specific treatment for PMS, highlighting the nee...

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Detalles Bibliográficos
Autores principales: Pagano, Jessica, Landi, Silvia, Stefanoni, Alessia, Nardi, Gabriele, Albanesi, Marica, Bauer, Helen F., Pracucci, Enrico, Schön, Michael, Ratto, Gian Michele, Boeckers, Tobias M., Sala, Carlo, Verpelli, Chiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394945/
https://www.ncbi.nlm.nih.gov/pubmed/37528484
http://dx.doi.org/10.1186/s13229-023-00557-2

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