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Neutralizing activity of intravenous immune globulin products against enterovirus D68 strains isolated in Japan

BACKGROUND: Enterovirus D68 (EV-D68), belonging to Enterovirus D, is a unique human enterovirus mainly associated with common respiratory diseases. However, EV-D68 can cause severe respiratory diseases, and EV-D68 endemic is epidemiologically linked to current global epidemic of acute flaccid myelit...

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Autores principales: Yoshida, Kazuhiro, Muramatsu, Masamichi, Shimizu, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394975/
https://www.ncbi.nlm.nih.gov/pubmed/37464326
http://dx.doi.org/10.1186/s12879-023-08429-z
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author Yoshida, Kazuhiro
Muramatsu, Masamichi
Shimizu, Hiroyuki
author_facet Yoshida, Kazuhiro
Muramatsu, Masamichi
Shimizu, Hiroyuki
author_sort Yoshida, Kazuhiro
collection PubMed
description BACKGROUND: Enterovirus D68 (EV-D68), belonging to Enterovirus D, is a unique human enterovirus mainly associated with common respiratory diseases. However, EV-D68 can cause severe respiratory diseases, and EV-D68 endemic is epidemiologically linked to current global epidemic of acute flaccid myelitis. METHODS: In this study, we measured neutralizing antibody titers against six clinical EV-D68 isolates in nine intravenous immune globulin (IVIG) products commercially available in Japan to assess their potential as therapeutic options for severe EV-D68 infection. RESULTS: Seven IVIG products manufactured from Japanese donors contained high neutralizing antibody titers (IC(50) = 0.22–85.01 µg/mL) against all six EV-D68 strains. Apparent differences in neutralizing titers among the six EV-D68 strains were observed for all IVIG products derived from Japanese and non-Japanese blood donors. CONCLUSIONS: High levels of EV-D68–neutralizing antibodies in IVIG products manufactured from Japanese donors suggest that anti-EV-D68 antibodies are maintained in the Japanese donor population similarly as found in foreign blood donors. Apparent differences in neutralizing antibody titers against the six EV-D68 strains suggest distinct antigenicity among the strains used in this study regardless of the genetic similarity of EV-D68.
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spelling pubmed-103949752023-08-03 Neutralizing activity of intravenous immune globulin products against enterovirus D68 strains isolated in Japan Yoshida, Kazuhiro Muramatsu, Masamichi Shimizu, Hiroyuki BMC Infect Dis Research BACKGROUND: Enterovirus D68 (EV-D68), belonging to Enterovirus D, is a unique human enterovirus mainly associated with common respiratory diseases. However, EV-D68 can cause severe respiratory diseases, and EV-D68 endemic is epidemiologically linked to current global epidemic of acute flaccid myelitis. METHODS: In this study, we measured neutralizing antibody titers against six clinical EV-D68 isolates in nine intravenous immune globulin (IVIG) products commercially available in Japan to assess their potential as therapeutic options for severe EV-D68 infection. RESULTS: Seven IVIG products manufactured from Japanese donors contained high neutralizing antibody titers (IC(50) = 0.22–85.01 µg/mL) against all six EV-D68 strains. Apparent differences in neutralizing titers among the six EV-D68 strains were observed for all IVIG products derived from Japanese and non-Japanese blood donors. CONCLUSIONS: High levels of EV-D68–neutralizing antibodies in IVIG products manufactured from Japanese donors suggest that anti-EV-D68 antibodies are maintained in the Japanese donor population similarly as found in foreign blood donors. Apparent differences in neutralizing antibody titers against the six EV-D68 strains suggest distinct antigenicity among the strains used in this study regardless of the genetic similarity of EV-D68. BioMed Central 2023-07-18 /pmc/articles/PMC10394975/ /pubmed/37464326 http://dx.doi.org/10.1186/s12879-023-08429-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Yoshida, Kazuhiro
Muramatsu, Masamichi
Shimizu, Hiroyuki
Neutralizing activity of intravenous immune globulin products against enterovirus D68 strains isolated in Japan
title Neutralizing activity of intravenous immune globulin products against enterovirus D68 strains isolated in Japan
title_full Neutralizing activity of intravenous immune globulin products against enterovirus D68 strains isolated in Japan
title_fullStr Neutralizing activity of intravenous immune globulin products against enterovirus D68 strains isolated in Japan
title_full_unstemmed Neutralizing activity of intravenous immune globulin products against enterovirus D68 strains isolated in Japan
title_short Neutralizing activity of intravenous immune globulin products against enterovirus D68 strains isolated in Japan
title_sort neutralizing activity of intravenous immune globulin products against enterovirus d68 strains isolated in japan
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394975/
https://www.ncbi.nlm.nih.gov/pubmed/37464326
http://dx.doi.org/10.1186/s12879-023-08429-z
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