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Neutralizing activity of intravenous immune globulin products against enterovirus D68 strains isolated in Japan
BACKGROUND: Enterovirus D68 (EV-D68), belonging to Enterovirus D, is a unique human enterovirus mainly associated with common respiratory diseases. However, EV-D68 can cause severe respiratory diseases, and EV-D68 endemic is epidemiologically linked to current global epidemic of acute flaccid myelit...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394975/ https://www.ncbi.nlm.nih.gov/pubmed/37464326 http://dx.doi.org/10.1186/s12879-023-08429-z |
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author | Yoshida, Kazuhiro Muramatsu, Masamichi Shimizu, Hiroyuki |
author_facet | Yoshida, Kazuhiro Muramatsu, Masamichi Shimizu, Hiroyuki |
author_sort | Yoshida, Kazuhiro |
collection | PubMed |
description | BACKGROUND: Enterovirus D68 (EV-D68), belonging to Enterovirus D, is a unique human enterovirus mainly associated with common respiratory diseases. However, EV-D68 can cause severe respiratory diseases, and EV-D68 endemic is epidemiologically linked to current global epidemic of acute flaccid myelitis. METHODS: In this study, we measured neutralizing antibody titers against six clinical EV-D68 isolates in nine intravenous immune globulin (IVIG) products commercially available in Japan to assess their potential as therapeutic options for severe EV-D68 infection. RESULTS: Seven IVIG products manufactured from Japanese donors contained high neutralizing antibody titers (IC(50) = 0.22–85.01 µg/mL) against all six EV-D68 strains. Apparent differences in neutralizing titers among the six EV-D68 strains were observed for all IVIG products derived from Japanese and non-Japanese blood donors. CONCLUSIONS: High levels of EV-D68–neutralizing antibodies in IVIG products manufactured from Japanese donors suggest that anti-EV-D68 antibodies are maintained in the Japanese donor population similarly as found in foreign blood donors. Apparent differences in neutralizing antibody titers against the six EV-D68 strains suggest distinct antigenicity among the strains used in this study regardless of the genetic similarity of EV-D68. |
format | Online Article Text |
id | pubmed-10394975 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-103949752023-08-03 Neutralizing activity of intravenous immune globulin products against enterovirus D68 strains isolated in Japan Yoshida, Kazuhiro Muramatsu, Masamichi Shimizu, Hiroyuki BMC Infect Dis Research BACKGROUND: Enterovirus D68 (EV-D68), belonging to Enterovirus D, is a unique human enterovirus mainly associated with common respiratory diseases. However, EV-D68 can cause severe respiratory diseases, and EV-D68 endemic is epidemiologically linked to current global epidemic of acute flaccid myelitis. METHODS: In this study, we measured neutralizing antibody titers against six clinical EV-D68 isolates in nine intravenous immune globulin (IVIG) products commercially available in Japan to assess their potential as therapeutic options for severe EV-D68 infection. RESULTS: Seven IVIG products manufactured from Japanese donors contained high neutralizing antibody titers (IC(50) = 0.22–85.01 µg/mL) against all six EV-D68 strains. Apparent differences in neutralizing titers among the six EV-D68 strains were observed for all IVIG products derived from Japanese and non-Japanese blood donors. CONCLUSIONS: High levels of EV-D68–neutralizing antibodies in IVIG products manufactured from Japanese donors suggest that anti-EV-D68 antibodies are maintained in the Japanese donor population similarly as found in foreign blood donors. Apparent differences in neutralizing antibody titers against the six EV-D68 strains suggest distinct antigenicity among the strains used in this study regardless of the genetic similarity of EV-D68. BioMed Central 2023-07-18 /pmc/articles/PMC10394975/ /pubmed/37464326 http://dx.doi.org/10.1186/s12879-023-08429-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Yoshida, Kazuhiro Muramatsu, Masamichi Shimizu, Hiroyuki Neutralizing activity of intravenous immune globulin products against enterovirus D68 strains isolated in Japan |
title | Neutralizing activity of intravenous immune globulin products against enterovirus D68 strains isolated in Japan |
title_full | Neutralizing activity of intravenous immune globulin products against enterovirus D68 strains isolated in Japan |
title_fullStr | Neutralizing activity of intravenous immune globulin products against enterovirus D68 strains isolated in Japan |
title_full_unstemmed | Neutralizing activity of intravenous immune globulin products against enterovirus D68 strains isolated in Japan |
title_short | Neutralizing activity of intravenous immune globulin products against enterovirus D68 strains isolated in Japan |
title_sort | neutralizing activity of intravenous immune globulin products against enterovirus d68 strains isolated in japan |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10394975/ https://www.ncbi.nlm.nih.gov/pubmed/37464326 http://dx.doi.org/10.1186/s12879-023-08429-z |
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