Continuous flow synthesis of pyridinium salts accelerated by multi-objective Bayesian optimization with active learning

We report a human-in-the-loop implementation of the multi-objective experimental design via a Bayesian optimization platform (EDBO+) towards the optimization of butylpyridinium bromide synthesis under continuous flow conditions. The algorithm simultaneously optimized reaction yield and production ra...

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Detalles Bibliográficos
Autores principales: Dunlap, John H., Ethier, Jeffrey G., Putnam-Neeb, Amelia A., Iyer, Sanjay, Luo, Shao-Xiong Lennon, Feng, Haosheng, Garrido Torres, Jose Antonio, Doyle, Abigail G., Swager, Timothy M., Vaia, Richard A., Mirau, Peter, Crouse, Christopher A., Baldwin, Luke A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10395269/
https://www.ncbi.nlm.nih.gov/pubmed/37538827
http://dx.doi.org/10.1039/d3sc01303k

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