P19 Burden of illness and costs among female patients with uncomplicated urinary tract infection in England

BACKGROUND AND OBJECTIVES: Uncomplicated urinary tract infection (uUTI) is usually community-acquired. Data regarding the wider burden of illness from uUTI are scarce. We evaluated the burden of uUTI in female patients in England. METHODS: This retrospective comparative cohort study utilized linked anonymized patient data from 1 January 2017 to 29 February 2020 from the Clinical Practice Research Datalink (CPRD) and English Hospital Episode Statistics databases. All eligible patients were female, aged ≥12 years and had ≥12 months’ CPRD data available pre- and post-index (i.e. ≥24 months total). Patients with an index UTI diagnosis who had received ≥1 oral antibiotic within ±5 days of index formed the uUTI cohort; uUTI episodes were defined as 28 days from index diagnosis. Patients who had visited a primary care setting but did not have a UTI (uUTI or complicated UTI [cUTI]) diagnosis during the study period formed the control cohort and were matched to the index date of uUTI patients. Patients who were hospitalized or visited an accident and emergency department 28 days prior to index, had cUTI and/or had received IV antibiotics as initial therapy were excluded. Burden of illness (index/12 month follow-up all-cause and UTI-related healthcare resource use [HCRU] and costs) was evaluated in a 1:1 age- and Charlson Comorbidity Index (CCI) score-matched cohort. RESULTS: Overall, 120519 female patients with uUTI and 233670 female control patients (without uUTI) were identified and matched 1:1. Before matching, more of the uUTI cohort patients versus controls were <50 years old, had a higher mean CCI score, and were more often menopausal; region- and practice-level differences were modest (Table 1). HCRU and costs were significantly higher among uUTI patients versus matched controls, notably for primary care, specialist, and accident and emergency visits, and hospital admissions (P<0.001, Table 2). After adjusting for patient characteristics, Poisson or negative binomial models showed significant HCRU differences in primary and secondary care for uUTI patients versus matched controls (Table 3). [Table: see text] [Table: see text] [Table: see text] CONCLUSIONS: Patients with uUTI in England had significantly higher burden of illness, consuming more resources, during index uUTI episodes and follow-up, versus matched controls.