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Impact of Residing in Below Median Household Income Districts on Outcomes in Patients with Advanced Barrett’s Esophagus

BACKGROUND: Barrett’s esophagus (BE) is a premalignant condition to esophageal adenocarcinoma (EAC). Low socioeconomic (SES) status adversely impacts care and outcomes in patients with EAC, but this has not been evaluated in BE. As the treatment of BE is similarly intensive, we aimed to evaluate the...

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Autores principales: Li, Suqing, Fujiyoshi, Yusuke, Jugnundan, Sechiv, May, Gary, Marcon, Norman, Mosko, Jeffrey, Teshima, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10395662/
https://www.ncbi.nlm.nih.gov/pubmed/37538188
http://dx.doi.org/10.1093/jcag/gwad018
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author Li, Suqing
Fujiyoshi, Yusuke
Jugnundan, Sechiv
May, Gary
Marcon, Norman
Mosko, Jeffrey
Teshima, Christopher
author_facet Li, Suqing
Fujiyoshi, Yusuke
Jugnundan, Sechiv
May, Gary
Marcon, Norman
Mosko, Jeffrey
Teshima, Christopher
author_sort Li, Suqing
collection PubMed
description BACKGROUND: Barrett’s esophagus (BE) is a premalignant condition to esophageal adenocarcinoma (EAC). Low socioeconomic (SES) status adversely impacts care and outcomes in patients with EAC, but this has not been evaluated in BE. As the treatment of BE is similarly intensive, we aimed to evaluate the effect of SES on achieving complete eradication of intestinal metaplasia (CE-IM), dysplasia (CE-D) and development of invasive EAC. METHODS: Our study was a retrospective cohort study. Consecutive patients between January 1, 2010, to December 31, 2018, referred for BE-associated high-grade dysplasia or intramucosal adenocarcinoma were included. Pre, intra and post-procedural data were collected. Household income data was collected from the 2016 census based on postal code region. Patients were divided into income groups relative to the 2016 median household income in Ontario. Multivariate regression was performed for outcomes of interest. RESULTS: Four hundred and fifty-nine patients were included. Rate of CE-IM was similar between income groups. Fifty-five per cent (n = 144/264) versus 65% (n = 48/264) in the below and above-income groups achieved CE-D, respectively, P = 0.02. Eighteen per cent (n = 48/264) versus 11% (n = 22/195) were found to have invasive EAC during their treatment course in below and above-income groups, respectively, P = 0.04. Residing in a below-median-income district was associated with developing invasive EAC (Odds Ratio, [OR] 1.84, 95% confidence interval [CI] 1.01 to 3.35) and failure to achieve CE-D (OR 0.64, 95% CI 0.42 to 0.97). CONCLUSIONS: Residing in low-income districts is associated with worse outcomes in patients with advanced BE. Further research is needed to guide future initiatives to address the potential impact of SES barriers in the optimal care of BE.
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spelling pubmed-103956622023-08-03 Impact of Residing in Below Median Household Income Districts on Outcomes in Patients with Advanced Barrett’s Esophagus Li, Suqing Fujiyoshi, Yusuke Jugnundan, Sechiv May, Gary Marcon, Norman Mosko, Jeffrey Teshima, Christopher J Can Assoc Gastroenterol Original Articles BACKGROUND: Barrett’s esophagus (BE) is a premalignant condition to esophageal adenocarcinoma (EAC). Low socioeconomic (SES) status adversely impacts care and outcomes in patients with EAC, but this has not been evaluated in BE. As the treatment of BE is similarly intensive, we aimed to evaluate the effect of SES on achieving complete eradication of intestinal metaplasia (CE-IM), dysplasia (CE-D) and development of invasive EAC. METHODS: Our study was a retrospective cohort study. Consecutive patients between January 1, 2010, to December 31, 2018, referred for BE-associated high-grade dysplasia or intramucosal adenocarcinoma were included. Pre, intra and post-procedural data were collected. Household income data was collected from the 2016 census based on postal code region. Patients were divided into income groups relative to the 2016 median household income in Ontario. Multivariate regression was performed for outcomes of interest. RESULTS: Four hundred and fifty-nine patients were included. Rate of CE-IM was similar between income groups. Fifty-five per cent (n = 144/264) versus 65% (n = 48/264) in the below and above-income groups achieved CE-D, respectively, P = 0.02. Eighteen per cent (n = 48/264) versus 11% (n = 22/195) were found to have invasive EAC during their treatment course in below and above-income groups, respectively, P = 0.04. Residing in a below-median-income district was associated with developing invasive EAC (Odds Ratio, [OR] 1.84, 95% confidence interval [CI] 1.01 to 3.35) and failure to achieve CE-D (OR 0.64, 95% CI 0.42 to 0.97). CONCLUSIONS: Residing in low-income districts is associated with worse outcomes in patients with advanced BE. Further research is needed to guide future initiatives to address the potential impact of SES barriers in the optimal care of BE. Oxford University Press 2023-04-27 /pmc/articles/PMC10395662/ /pubmed/37538188 http://dx.doi.org/10.1093/jcag/gwad018 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of the Canadian Association of Gastroenterology. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Li, Suqing
Fujiyoshi, Yusuke
Jugnundan, Sechiv
May, Gary
Marcon, Norman
Mosko, Jeffrey
Teshima, Christopher
Impact of Residing in Below Median Household Income Districts on Outcomes in Patients with Advanced Barrett’s Esophagus
title Impact of Residing in Below Median Household Income Districts on Outcomes in Patients with Advanced Barrett’s Esophagus
title_full Impact of Residing in Below Median Household Income Districts on Outcomes in Patients with Advanced Barrett’s Esophagus
title_fullStr Impact of Residing in Below Median Household Income Districts on Outcomes in Patients with Advanced Barrett’s Esophagus
title_full_unstemmed Impact of Residing in Below Median Household Income Districts on Outcomes in Patients with Advanced Barrett’s Esophagus
title_short Impact of Residing in Below Median Household Income Districts on Outcomes in Patients with Advanced Barrett’s Esophagus
title_sort impact of residing in below median household income districts on outcomes in patients with advanced barrett’s esophagus
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10395662/
https://www.ncbi.nlm.nih.gov/pubmed/37538188
http://dx.doi.org/10.1093/jcag/gwad018
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