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All aspects of sciatic nerve injection injury: an experiment with 78 rats

BACKGROUND/AIM: In this study, we evaluate sciatic nerve injuries due to intramuscular injections, which is an important medicolegal problem frequently encountered in medical practice, with an extended experimental rat model of peripheral nerve injury. MATERIALS AND METHODS: A total of 78 male Wista...

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Autores principales: ZEYNAL, Mete, KADIOĞLU, Hakan Hadi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Scientific and Technological Research Council of Turkey (TUBITAK) 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10395692/
https://www.ncbi.nlm.nih.gov/pubmed/36422486
http://dx.doi.org/10.55730/1300-0144.5499
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author ZEYNAL, Mete
KADIOĞLU, Hakan Hadi
author_facet ZEYNAL, Mete
KADIOĞLU, Hakan Hadi
author_sort ZEYNAL, Mete
collection PubMed
description BACKGROUND/AIM: In this study, we evaluate sciatic nerve injuries due to intramuscular injections, which is an important medicolegal problem frequently encountered in medical practice, with an extended experimental rat model of peripheral nerve injury. MATERIALS AND METHODS: A total of 78 male Wistar albino rats were divided into five main groups, including a control group, a sham saline group, and groups that received benzathine penicillin G, diclofenac sodium, and dexamethasone, respectively. These pharmaceutical agents were applied to the sciatic nerves of all rats after exploration in the epineurial, endoneurial, and intrafascicular compartments, excluding the control group. Outcomes were evaluated for all rats and their sciatic nerves according to functional, electrophysiological, and histopathological results. RESULTS: Injuries were most evident in the groups that received penicillin G and diclofenac sodium, and this finding was statistically significant. It was also found that endoneurial and intrafascicular injections may cause more harm than epineurial injections. CONCLUSION: We have demonstrated that any medical injections applied to the epineurial, endoneurial, or intrafascicular compartments of the sciatic nerve may cause functional and electrophysiological loss with or without deterioration of the peripheral nerve architecture.
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spelling pubmed-103956922023-08-03 All aspects of sciatic nerve injection injury: an experiment with 78 rats ZEYNAL, Mete KADIOĞLU, Hakan Hadi Turk J Med Sci Research Article BACKGROUND/AIM: In this study, we evaluate sciatic nerve injuries due to intramuscular injections, which is an important medicolegal problem frequently encountered in medical practice, with an extended experimental rat model of peripheral nerve injury. MATERIALS AND METHODS: A total of 78 male Wistar albino rats were divided into five main groups, including a control group, a sham saline group, and groups that received benzathine penicillin G, diclofenac sodium, and dexamethasone, respectively. These pharmaceutical agents were applied to the sciatic nerves of all rats after exploration in the epineurial, endoneurial, and intrafascicular compartments, excluding the control group. Outcomes were evaluated for all rats and their sciatic nerves according to functional, electrophysiological, and histopathological results. RESULTS: Injuries were most evident in the groups that received penicillin G and diclofenac sodium, and this finding was statistically significant. It was also found that endoneurial and intrafascicular injections may cause more harm than epineurial injections. CONCLUSION: We have demonstrated that any medical injections applied to the epineurial, endoneurial, or intrafascicular compartments of the sciatic nerve may cause functional and electrophysiological loss with or without deterioration of the peripheral nerve architecture. Scientific and Technological Research Council of Turkey (TUBITAK) 2022-08-04 /pmc/articles/PMC10395692/ /pubmed/36422486 http://dx.doi.org/10.55730/1300-0144.5499 Text en © TÜBİTAK https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License.
spellingShingle Research Article
ZEYNAL, Mete
KADIOĞLU, Hakan Hadi
All aspects of sciatic nerve injection injury: an experiment with 78 rats
title All aspects of sciatic nerve injection injury: an experiment with 78 rats
title_full All aspects of sciatic nerve injection injury: an experiment with 78 rats
title_fullStr All aspects of sciatic nerve injection injury: an experiment with 78 rats
title_full_unstemmed All aspects of sciatic nerve injection injury: an experiment with 78 rats
title_short All aspects of sciatic nerve injection injury: an experiment with 78 rats
title_sort all aspects of sciatic nerve injection injury: an experiment with 78 rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10395692/
https://www.ncbi.nlm.nih.gov/pubmed/36422486
http://dx.doi.org/10.55730/1300-0144.5499
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